Sapphire Energy, Backed by Bill Gates, Tries to Tone Down the Hype as it Makes Gasoline From Algae

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a handful of venture capital leaders began looking for the right technology. Typically, the innovator who develops a new technology looks for the right venture capital firms to provide funding for the idea.

Pyle says his discussions began with Kristina Burow, a chemist-turned-partner at Arch Venture Partners, biotech CEO Nathaniel David and scientist Mike Mendez. “We started analyzing different kinds of biofuel deals and technologies and asking ourselves what’s great about this and what’s not,” Pyle said.

After determining that their best prospect was to become a producer of gasoline and diesel fuels, Pyle says they set out to identify the best green technologies for making it. They found what they were looking for in the research of Stephen Mayfield, an algae biologist at The Scripps Research Institute in La Jolla, and Steven Briggs, a professor of cell and developmental biology at UC San Diego.

The founders and their scientific collaborators officially launched Sapphire in May 2007, and moved the headquarters from San Francisco to San Diego earlier this year.

In September, Sapphire generated a lot of buzz when it announced it raised $100 million in a second round of venture funding from ARCH Venture Partners, Venrock, the Wellcome Trust and Cascade Investment, a venture firm owned by Microsoft chairman Bill Gates. Pyle declined to say how much Sapphire has raised altogether.

With so much recent attention, it was perhaps inevitable that Pyle and other Sapphire leaders would step forward to publicly discuss their startup for the first time to the San Diego community.

The SDBN networking event drew scores of biotech workers Tuesday night, even though Pyle made no presentation. Hundreds of others attended presentations by two Sapphire scientists at a breakfast meeting hosted early Wednesday by Biocom, the San Diego industry group.

“Technologically speaking, we think of this as an immense challenge on the order of the Apollo (space) program or the Manhattan project,” Alex Aravanis, Sapphire’s senior director of BioEngineering told the Biocom audience.

Using genetic engineering and other techniques, Aravanis said a massively industrialized approach would be needed to grow algae in sufficient quantities to produce enough green crude to accommodate the 20 million barrels of crude oil consumed by the United States every day. Sapphire’s concept calls for creating enormous algae “farms” throughout the desert lands of the southwestern United States.

“This particular technology could be deployed at a very large scale, a scale that could make the U.S not only energy independent—but a net exporter of fuels,” Aravanis said.

He added that the algae developed by Sapphire can thrive in brackish saltwater, making it possible, perhaps, to tap sources of otherwise unusable water—such as the Salton Sea—to support such algae fields in the deserts east of San Diego.

It could take years to develop the necessary industrial processes, but Pyle says he’s excited and encouraged by everything that has happened and the interest generated so far.

“We’ve had conversations with all six of the largest oil companies in the world” he says.

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Bruce V. Bigelow is the editor of Xconomy San Diego. You can e-mail him at or call (619) 669-8788 Follow @bvbigelow

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  • Ok, to sum it up he says: “We can produce fuels from algae, but it’s too expensive”

    It’s so expensive that in spite of the excessive funding no more than one gallon of jet fuel from algae was available to test on the Japan Air Lines flight.


  • Sorry, one gallon -> one jerrycan.

  • PappaDaddy

    Sapphire Energy sounds like a scam. Sapphire says their “green crude” is chemically identical to gasoline. (Sirens going off!!!) GASOLINE is made up of varying chains of hydrogen and carbon. How does something chemically identical to gasoline not produce CO2 as a by-product? Any chemical engineers out there? As we’ve seen recently with the Maddow investment scam, because someone has money does not make them a good investor…or because Bill Gates knows software doesn’t make him a chemist.

    These companies are currently in business to milk up government funding and then disappear (or grab subsidies and disappear). There will be US government grants and loans pissed away soon under the new administration to anyone who sounds like they know anything about renewable energy. Banks are not going to loan these people money. The only place they will be able to get it is from our fearless leaders in government. There is NOT ONE independently verifiable algae fuel production facility on Earth. If there is please point it out and tell me where I can buy some “green crude”. Even a long-term pilot plant would do.

    That mental retard Rep Inslee from Washington state is a supporter of Sapphire. You can find his incoherent speech on the House floor on youtube.

  • George

    Of course it produces CO2 when it’s burned. Of course any CO2 in it came from the atmosphere. It’s carbon neutral, not carbon negative. Every molecule of CO2 that’s released when it’s burned was sucked out of the atmosphere during the production process. Like all plants do. Do some research before you start making wild accusations.

    There’s a long term pilot plant for you. From algae.

    The science behind algae is sound. The only thing that Sapphire Energy did differently is tweak the output molecule in interesting new ways to create something that can turn into gasoline, not ethanol.

  • PappaDaddy

    Hi George

    Do some research??? That’s funny. The science behind fuel cells and nuclear reactors is also sound, but a bit pricy. I won’t let economics get in the way of your fantasy though. The guy that Rep Inslee described is a venture capitalist, not the owner of the company. Did you listen to his speech? The man is a simpleton. That’s like me going to Congress and touting the virtues of all the companies I’m invested in.

    Interesting link and excellent “independently verifiable source”, but can you tell me where I can buy some of that PetroSun fuel? They say they make 5000-8000 gallons per acre per year and have several hundred acres leased. That post is a year old, so they should have some product available somewhere. Several articles say 4 million gallons per year and 110 million pounds of biomass. Maybe they just throw it away once they make it. Anything is possible for a company with a market capitalization of …put pinky to corner of mouth…”$1.28 MILLION DOLLARS!” That ticker is PSUD, but since you did so much research, you probably knew that. Certainly only every other person in my neighborhood has assets like that! That is coincidentally what PetroSun owes Shreveport Louisiana for reneging on the deal to sponsor a college football bowl game:–15964/

    On the “carbon neutral thing, I knew I would get that argument as soon as I posted. I wonder though if “every molecule is sucked out of the air” and none comes from the ground or whatever they are feeding it? Can you verify that no carbon is pulled from other sources and that “every molecule” comes from the atmosphere? They say they use the open pond method. Can you explain how their algae compete with the local strains? In a 2006 newsletter Mr Hung, owner of the fish farm (oops, I mean biofuels plant), mentions the local algae there:

    The Arroyo Colorado River, only four nautical miles upstream from the hyper saline Laguna Madre Bay. Our average salinity is around 5 to 15 parts per thousand and the water is rich in algae.

    This is SNAKE OIL pure and simple!

  • PappaDaddy

    George?…anybody seen George?

    Well that fine example of an algae plant” Petrosun, Symbol PSUD, is now worth a whopping $810,000! I’m gonna invest that cash I had set aside for an up and coming jock strap recycling company to invest in this baby! Wait a minute, I can use the carbon in the old jock straps to feed the algae! It’s a scientific fact that scrotums contain 10,000 times more carbon than…well you never mind…this is a sure thing right George? George?

  • nose2grindstone

    Chemical engineering is far more complicated then A + B = C; With the right catalysts, pressures, temperatures, separations, ect. We get A+B+Z = JP 8.

    I don’t know about Sapphire’s success specifically, but they could be doing it.

  • Linda Dow

    I know about this, and all would be fine, as it is possible if you work really hard. What I want to know is the name of the company, that has been receiving government funding to ‘research algae production of fuel’ since the 1970’s, and all they have done is fund the establishment of over 1100 patents on different algae gene profiles, so that when someone ELSE finally makes some fuel, they will get some money.

  • SanDiegoGreen

    Its not a scam, I recently interviewed there and I am a chemical engineer.

  • PappaDaddy

    DanDiego Green

    I have no doubt you interviewed there, but can you please tell me where the company’s revenue is from? Could it be grants from the Feds?

    How much is this magic fuel per gallon?

    Soalzyme Corp in South San Francisco just won a contract for over $8 million for 20,055 gallons…do the math.

  • Mike

    PappaDaddy get over yourself… seriously. Their revenue is not from profits, but from investors. Don’t forget the first computers had a fraction of todays PC power and filled a room or building. Or the first Plasm screen TVs cost around 10,000 and now are available at best buy for a 1/10 of the cost. Of course your probably believe there was never a man on the moon, so what’s the point. Bottom line is our future is unsustainable and we need companies like Sapphire and investors like Bill Gates to change the way we think…

  • PDaddy

    Well here we are nearly 3 years after the original post and how’s that algae fuel working out? Anyone? Anyone? I haven’t responded to Mike’s suggestion on “getting over” myself until I did a retake of Economics classes. I saw no mention of investments being listed as revenues. Curious. Unlike Mike, I think for myself and do NOT require any swingin’ &^%$#* to tell me how to think. You should try it Mike…Very liberating.

  • asdasdffasdasdf

    Sapphire = biggest scam company out there that seeks to milk government funds and investors’ money lol…

    No specie of known algae produce lipid composition that is identical to crude oil. Thats why majority of biofuels research is based on biodiesel – microalgae produce lipid in form of TAG, which undergoes transesterification to be converted into diesel.

  • spin43

    I am so glad our government is not in debt and has money to throw at these scams. Taxpayers lose again as crony capitalism prevails under BHO.