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Flagship’s Pronutria Emerges to Make Medicines and Medical Foods

Xconomy Boston — 

Sometimes there may be good protein drugs lurking in your lunch and you just don’t know it. There may be a business in there, too.

That’s one way to look at the latest concept being cooked up at Flagship VentureLabs in Cambridge, MA. The young company, Pronutria, is emerging from stealth mode today after more than two years of work and $10.8 million of investment from Flagship Ventures. The company is publicly discussing its idea for the first time after getting enough technology validation—and enough intellectual property filings—that it’s ready to talk with partners about its unusual approach to drug development and medical foods, says Noubar Afeyan, Flagship’s managing partner.

Pronutria hopes to come up with drugs from an unusual source. It has put together a library of the DNA sequences for making certain amino acids that scientists say have a positive health effect, sort of like how Omega-3 fatty acids are thought to help prevent cardiovascular disease. While some of these amino acids can be found in various forms in nutritional supplements you can get at the local GNC—think whey protein shakes for building muscle—these tend to be mixtures and byproducts that aren’t made with the same purity, balanced ratio of ingredients, and consistency of regulated pharmaceuticals. That means that these products, despite the sometimes breathless hype, can’t make health claims with scientific credibility.

Pronutria is betting that it can make some of these desirable proteins found in the human diet, and make them in purified form, in the right doses and combinations, so that they will deliver a consistent health benefit supported by science. GlaxoSmithKline already has shown that a so-called fish oil-derived “pharmaconutrient” made of purified Omega-3-acid ethyl esters (Lovaza) can make a lot of money. Pronutria’s hope is that it can have similar success creating other such pharmaconutrients, while maintaining a strong scientific reputation that separates it from the protein supplements hawked on TV infomercials.

Robert Connelly, CEO of Pronutria

Robert Connelly, CEO of Pronutria

“We believe we have a platform that can produce the next 10 to 20 Lovazas,” said Robert Connelly, CEO of Pronutria. “We want to stay out of pseudoscience.”

Pronutria was founded in 2010 by Afeyan, David Berry, and Geoffrey von Maltzahn in the same operation (VentureLabs) that started Moderna Therapeutics, Joule Unlimited, and Seres Health. In addition to Afeyan, Berry, and Connelly, the Pronutria board of directors includes Charles Cooney, an MIT professor of chemical engineering; Glenn Nedwin, a former president of Novozymes, an industrial enzymes giant; and Gary Pisano, a professor at Harvard Business School. The company currently has 24 employees, Connelly says.

The company plans to make its pharmconutrients with industrial biological processes that use microbial hosts, like those of common biotech drugs, Afeyan says. It is focusing on amino acids that have been validated as having health benefits by scientists, which can be delivered as proteins in pills or drinks, which don’t spark allergic reactions, and which don’t taste awful. Pronutria’s plan is to move swiftly into human clinical trials with its protein drug candidates, and sidestep a lot of the usual preclinical work for new molecular drug entities, because its proteins are already components of the human diet that are considered GRAS—an FDA abbreviation for “generally regarded as safe.” By going ahead with GRAS proteins, the firm hopes to head down a drug development path that’s faster and cheaper than what most compounds have to follow today.

The first protein to emerge from Pronutria’s platform is one for sarcopenia, the name for muscle loss associated with aging. Another product candidate is being geared to help elderly people recover from falls, Connelly said. Others in the pipeline are being eyed for phenylketonuria, inflammatory bowel disease, and cystic fibrosis. Part of the secret in making these products work will be in getting the right dosages, the right ratios of amino acids, and getting them to the right degree of solubility, he said.

“We’re putting the pharmacology first,” Afeyan says. “If we don’t see a dose/response relationship, repeatability across many people, and proper controls, then we’re not going forward.” He adds: “Since it’s from food, we are making a product recapitulating the optimal amino acid compositions that people have tied to health effects.”

Noubar Afeyan, managing partner, Flagship Ventures

Noubar Afeyan, managing partner, Flagship Ventures

Just to use a popular example, it’s possible to come up with a pharmaceutical-grade version of Omega-3 fatty acids, and a dietary supplement form of the same thing, which call for quite different business models. The pharmaceutical forms would come at higher prices, be marketed to physicians instead of consumers, and rely on a different distribution system. Medical foods also come with different regulatory requirements and standards. Pronutria hopes to handle the different issues by leaning on partners, Connelly says.

There could be tons of competitors for Pronutria, and they would vary from protein to protein that it aspires to make. To his knowledge, Afeyan says no other company has been set up to create a library of the proteins in the human diet, with an eye toward making some of them into pharmaceuticals, medical foods, and dietary supplements. “There are places to call and order an amino acid drink or mix, but they’re very expensive, taste terrible, and are not specialized to your needs,” Afeyan says.

The biggest challenge at the startup?

“Focus,” Connelly says. “For me, this is a cross-indication platform. There are a lot of different places you could go with it. We’ve generated many leads. We’re closing in on 40 lead [candidates], across many different indications. Once you have these preclinically assessed, what do you take forward? We’re trying to assess areas to focus on.”

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  • Gerald Bostock

    Who needs a press release when you have Xconomy? But yeah, “a library of the DNA sequences for making certain amino acids that scientists say have a positive health effect”, sounds pretty revolutionary.