Funding for clean technology startups has increased substantially in recent years, with 323 U.S. companies raising a total of $4.3 billion in 2011, according to the recently released MoneyTree Report. In the San Diego area, the same report shows that four cleantech startups raised $78 million last year, including $15 million that went to SG Biofuels in the fourth quarter.

But sometimes it’s not enough to be green. Many cleantech startups face a basic challenge in competing against existing products that might not be as environmentally friendly, but are nevertheless well-established—even commoditized—in their respective markets.

In San Diego, sustainable design architect (and Xconomist) Robert Noble has led the development of clean manufacturing methods and technologies for manufacturing a green replacement for medium density fiberboard (MDF) structural panels—a standard material used in building construction and other industries. Noble says the proprietary process makes panels from any kind of fibrous, cellulosic material, such as recycled paper, cardboard, wood chips, corn stalks, and even cow manure. The big difference is that the replacement product, which Noble calls 3-D Engineered Molded Fiber (3DEMF), requires no petroleum-based glues or addititves, or vapor-emitting chemicals.

Ecor samples

Now Noble Environmental Technologies, a company he founded in 2005, is overseeing installation of a 3DEMF factory, showroom, and design lab in downtown San Diego to manufacture the company’s Ecor brand panels. “The tide has turned for sustainable materials,” says Jim Torti, the company’s chief operating officer.

After personally funding the company through 2009, Noble says he now has about 15 individual and institutional investors, and he’s in the process of raising another $4 million to help equip the 10,000-square foot factory and to provide some cash flow. Noble adds that he has no plans to seek venture capital. He says the time required to build large-scale manufacturing and their primary market—the building industry—”doesn’t easily fit the venture capital model for a quick exit,” which is an issue for many cleantech businesses.

Torti and Noble say they wanted to establish the company’s first production plant in an urban, mixed-use setting—an apartment building is across the street—to demonstrate … Next Page »

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[Corrected 2/9/12, 9:05 a.m. See below.] A few weeks ago, Dan Gilbert and the Detroit Venture Partners (DVP) crew welcomed reporters for a tour of the newly renovated Madison Building in downtown Detroit. Gilbert had recently spent $12 million to turn the former theater into a sort of fantasy workspace for budding entrepreneurs, and the results of his makeover didn’t disappoint.

The building features plenty of walls that function as whiteboards, a 150-seat auditorium that seems the perfect place to host an investor pitch meeting, and a stunning rooftop kitchen and deck that overlook Comerica Park, home of the Detroit Tigers. Little flourishes, like the exposed brick and the fact that some of the graffiti found in the building during renovations has been preserved, give the space a young, slightly edgy feel. All of it is meant to transform the Madison Building into a destination for startups across the nation—and if the story of Quikkly‘s Shawn Geller is any indication, it’s working.

Geller, a native of Pennsylvania, graduated from Temple University in 2009. While in school, he was bothered by what he saw as a disconnect between the small mom and pop stores surrounding the campus and the students they sought as customers.

“It wasn’t just local stores, but even the national brands would only come on campus one day a year with student ambassadors,” Geller says, noting the cost and inefficiency of that strategy. “It wasn’t a good model whatsoever.”

Geller worked with local merchants in need of promotion to create a simple landing page where students could find coupons and send them to their phones via text message. They would then claim the coupon by showing the text message at the store offering the discount.

Word of mouth quickly spread, and Geller built up a database of about 3,000 Temple students. He then went around to different restaurants and stores and asked them what their slowest times and days were. Armed with that information, he created his first “flash deal,” where he sent a text out to his database offering the first 150 people who responded within a certain amount of time a large pizza for $5. When close to 100 students went in to the pizzeria to claim their coupons, Geller knew he was onto something.

“It was a very cool way of testing the market,” Geller says. “Groupon was less relevant then, so it was exciting to be able to drive student interest in such a short amount of time.”

Geller began incorporating Facebook social gestures into his platform and named his startup Student Coupons. Soon, friends who didn’t attend Temple were noticing the Facebook posts and asking how they, too, could take advantage of the coupons.

Geller starting working with Jason Lorimer, another Philly entrepreneur, to refine and scale up his business model. Lorimer had just begun spending time in Detroit first as a tourist visiting a friend, and then as an entrepreneur scouting for opportunities. Lorimer connected Geller with Josh Linkner, DVP’s managing partner, after he saw some common ground between the national brands Geller hoped to snag as clients … Next Page »

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OncoSec Medical CEO Punit Dhillon tells me the startup he helped establish in San Diego last March is beginning mid-stage safety and efficacy trials of its proprietary technology for enhancing drug delivery in treatments of several types of skin cancer.

The technology, which OncoSec acquired from Blue Bell, PA-based Inovio Pharmaceuticals (AMEX: INO) almost a year ago, transmits intense electrical pulses into skin tumors through six electrode needles that are pushed into the skin. The electricity causes the tumor cells to become permeable with each jolt, and makes it easier for anti-cancer drugs injected into the region to pass through the tumor cells’ tough outer membrane. Known as electroporation, the process increases the concentration of an anti-cancer drug within the tumor.

“What we’re doing is a much more elegant and targeted approach,” says Dhillon, who estimates the technique increases the uptake of anti-cancer drugs by 4,000 to 10,000 times. As a result, doctors can reduce the dosage of anti-cancer drugs used with electroporation technology.

Dhillon, who previously served as Inovio’s vice president of finance and operations, says Inovio has been an electroporation pioneer. The Pennsylvania company decided last year, however, to sell technology that was unrelated to its strategic focus on developing DNA vaccines for cervical dysplasia, leukemia, and hepatitis C virus therapies.

The deal to acquire Inovio’s assets didn’t happen by chance. Inovio chairman and former CEO Avtar Dhillon is Punit Dhillon’s uncle, and their family and friends raised the initial $1.1 million that funded OncoSec after the company sprang to life through a reverse merger with a dormant public company. The San Diego startup raised another $3 million last June from two New York health funds, Hudson Bay Capital and Heights Capital. That should be enough cash for OncoSec to complete three mid-stage trials the company plans to begin before the end of March.

The three studies will use OncoSec’s electroporation technology to deliver the company’s lead drug candidate, called Interleukin-12 (IL-12) cytokine, to three groups of patients with different lethal skin cancers—metastatic melanoma, Merkel cell carcinoma, and cutaneous T-cell lymphoma. The experimental drug is intended to both trigger and boost a strong immune response to each type of cancer. The combined treatment, known as electroimmunotherapy, represents a potential new anti-cancer treatment with broad applicability, although Punit Dhillon says the company must pursue separate regulatory approvals to treat each type of cancer (as a combination drug-and-device product) on an application-by-application basis.

OncoSec says its technology also can be used in the same way in electrochemotherapy, which uses an established anti-cancer drug like bleomycin while a tumor is being electroporated. The use of electroporation in chemotherapy has been studied more throroughly, and Punit Dhillon says he wants to advance OncoSec’s approach through a partnership with a bigger pharmaceutical company.

“2011 was a great year for us,” he says, “and we’ve got some exciting milestones to look forward to in 2012.” Once the latest studies have been completed, OncoSec’s Dhillon says he looks forward to licensing opportunities and other commercial prospects, and he adds, “We also still have the chemotherapy program in the wings.”

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She started her career as a management consultant, but Aubrie Pagano says she always knew she wanted to be an entrepreneur. And she was particularly energized by fashion.

So Pagano spent her free hours assisting local Boston designer Emily Muller in launching her collection, in exchange for the opportunity to get some firsthand experience in the independent fashion design space. There she discovered that designers face a particular challenge—one that would eventually inspire Pagano to create the e-commerce startup Zoora.

“Its hard for independent designers to scale because there’s a discovery issue,” says Pagano. “[Muller] has a great website buts nobody goes to it.”

And as a shopper, Pagano says she’s felt like she’s had to settle for a piece of clothing that just isn’t quite right. Women like her are the perfect customer base for independent designers, she says.

“Something that a lot of people don’t know about independent designers is that they’re really flexible,” Pagano says.

Just last Monday, Pagano opened the Zoora website to the public, to offer women clothing that they can customize to best fit their measurements and taste. Her hope is that the women who feel underserved by traditional retail will bring independent designers the traffic—and business—they so desperately need.

Zoora joins a booming cluster of Boston companies in the space of mass customization, where e-commerce platforms allow shoppers to select and tailor products to better fit their preferences. As my colleague Greg has pointed out previously, these companies offer shoppers personalized jewelry (Gemvara), bags (F. Rock), girls clothing (FashionPlaytes), men’s dress shirts (Boston’s Blank Label and Proper Cloth in New York), and even bras (Zyrra).

Pagano started working on Zoora (a name inspired by “misura,” the Italian word for measurement) last spring, and made hiring a head buyer her first move. Since then, the company has enlisted about a dozen designers (including Muller) to sell garments on the site with options for customization. Another designer is Althea Harper, a former contestant on the Lifetime show Project Runway. (Worth noting, New York fashion tech startup Send the Trend has Project Runway veteran and winner Christian Siriano on staff.)

The customizations to Zoora garments fall into two baskets, says Pagano: “made-to-measure adjustments” and “ready-to-wear tweaks.” With the first category, customers input their specific measurements, which designers take into account to create a garment that’s a perfect fit. With “ready-to-wear tweaks,” meanwhile, garments come in standard sizes, but offer different options for elements like fabric, necklines, sleeves, and hem length.

The Zoora team now consists of … Next Page »

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Applied Proteomics hasn’t exactly been operating in stealth mode since it was founded five years ago. Co-founders David Agus, a cancer specialist at USC, and Danny Hillis, the MIT-trained computer scientist, gave TedMed talks about the startup’s technology, which provides a 40-gigabyte snapshot of all the proteins circulating in a drop of blood. By pure coincidence, I watched John Stewart’s Feb. 2 interview with Agus last night on “The Daily Show.”

“Danny and David had the foresight to build the tool before trying to use the tool,” says John Blume, a molecular biologist who joined API in 2008 as chief scientific officer. “Although the company wasn’t in stealth mode, the first several years were spent in taking the time to make it right, and then to use it and avoid some of the stumbling blocks.”

Now Applied Proteomics is raising the curtain on several steps that mark its progress beyond a seed-stage startup that was incubating at Applied Minds, an industrial think tank that Hillis founded in Glendale, CA, with a colleague from Disney Imagineering. After moving the headquarters to San Diego late last year, Applied Proteomics is today naming a new CEO—Peter Klemm, a veteran in molecular diagnostics and the former CEO of Lexington, MA-based Predictive Biosciences.

Danny Hillis

The company known as API says it also secured $22.5 million last June in Series B funding from Domain Associates (San Diego partner Jim Blair joined the board), Seattle’s Vulcan Capital, and returning angel investors. Klemm tells me the company raised $4 million from angel investors (who prefer to go unnamed) in what amounted to API’s Series A round in 2007.

David Agus

API’s goal, Klemm says, is nothing less than to “elevate molecular diagnostics to another level beyond the genome” by measuring the proteins made by genes—a long-sought technology that is expected to help doctors improve medical care for individual patients. Because proteins carry out most cellular functions, the company says a snapshot of all the proteins circulating in the body at a given moment represents “the most powerful source of information” in terms of understanding a patient’s health status.

Quantifying all the proteins in the body, Klemm says, can help doctors optimize the course of treatment for individual patients by making it easier to identify the specific drugs that would have the greatest effect on blocking specific proteins or signaling pathways, which can vary dramatically from person to person.

In a statement from the company, Hillis says, “For the first time, we can look at all the proteins in the body with remarkable specificity and sensitivity and use proteomic technology to create … Next Page »

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We’re starting to see fresh signs of life among the Internet software startups in San Diego. Check out this news.

—During a visit last week, TechStars CEO David Cohen talked with the leaders of San Diego’s grassroots Web startup community about the factors that help to create and sustain entrepreneurial communities. One crucial issue confronting San Diego is a crying need for savvy and experienced Internet entrepreneurs who are willing to “pay it forward” by mentoring a new generation of startups.

—A dozen seed-stage companies moved into the new EvoNexus incubator in downtown San Diego. EvoNexus, which was founded by the CommNexus non-profit industry group, will continue to operate its original incubator in University City, where eight startups are taking root. In both locations, EvoNexus provides office space, utilities, and other services free of charge and with no strings attached.

—Sigma Partners led a $10 million round in venture funding for San Diego-based MOGL, a Web startup that has developed a comprehensive customer loyalty program for restaurants and bars, to fuel its expansion into San Francisco and New York. San Diego’s Avalon Ventures and Austin, TX-based Austin Ventures joined in the round.

—San Diego’s MicroPower Technologies named two new board members after raising $6.5 million in Series C funding in a deal that was led by Motorola Solutions Venture Capital and joined by an undisclosed private fund. MicroPower Technologies, which uses wireless networking technologies to create low-cost surveillance capabilities, named PacketVideo CEO Jim Brailean and former DivX CEO Kevin Hell to its board. Hell, who is now chairman of San Diego’s EvoNexus incubator, will join as MicroPower chairman.

—San Diego’s StockTwits said it has established a partnership with Toronto’s Q4 Web Systems, which provides … Next Page »

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Citizen Effect, the Washington, D.C.-based microphilanthropy organization that is perhaps best known for its work in India, has just launched a new initiative called Detroit4Detroit, which aims to fund 150 community-improvement projects using a strategy that’s heavy on social networking and other digital tools.

“Detroit4Detroit is based around the idea that anyone can be a philanthropist,” says Eric Moss, Detroit4Detroit’s project manager. “It’s about actualizing our power and actualizing our social networks.”

Citizen Effect organizers work with its partners—ACCESS, Brightmoor Alliance, COTS, Detroit Area Pre-College Engineering Program (DAPCEP), SER Metro Detroit, Wellspring, and Vanguard—to curate a list of viable projects, with each submitting five to ten projects for consideration. Once a project has been vetted, it’s posted to the Detroit4Detroit website for a citizen philanthropist, or CP, to adopt. Once a project has been claimed, Citizen Effect gives the CPs a digital toolkit that enables them to promote the project on sites like Facebook and Twitter, reach out to potential supporters through fundraising emails, and have an online platform to post blogs, videos, and photos related to the project.

The goal of Detroit4Detroit is to have 150 people raising $250,000 across 150 projects, though Moss says this initial target is a starting point for what he hopes will be “limitless” community philanthropy.

“I’m blown away by the enthusiasm and how many people want to sign up,” says Matt Bailey, who manages the tech and data side of Detroit4Detroit’s operations. Though the initiative just held its formal launch last month, 15 people have already signed on to be CPs and are in the process of being matched with the project that best suits their talents, interests, and networks. (One project has officially started fundraising.)

The Detroit4Detroit model was developed with the help of the Knight Foundation, and represents the first time Citizen Effect has launched a microphilanthropy initiative of this kind in an American city.

“This is a special moment in Detroit,” Moss says, noting that the city is alive with grassroots energy. “We want to fit into the revitalization and renewal efforts in a way where we engage each other about the idea of philanthropy. We all can make a difference, especially if we’re provided with the tools that level the playing field.”

Moss is himself representative of the kind of change that is rapidly taking root in the city, where people who grew up in greater Detroit but left to attend college or seek work are returning to the area with a sense of purpose. Moss grew up in suburban Detroit, went to college in D.C., and lived in New York and Los Angeles before making his way back home.

“I moved back two years ago and I came back willingly,” Moss says. “What brought me back was the soul of the city, which was missing in the other places I lived. There’s an electric energy going on here that none of us can deny. It’s a great opportunity to experience this very positive transition of order out of chaos.”

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—San Diego’s Amylin Pharmaceuticals says Bydureon, its new once-a-week drug for treating Type 2 diabetes can hit the market as early as next month, after the FDA cleared Bydureon. The FDA rejected the Amylin’s drug twice before. An estimated 26 million people in the United States, or roughly 8 percent of the population, have type 2 diabetes.

—San Diego’s life sciences sector has expanded since 2009, with employment increasing by more than 5,550 jobs, or 15 percent, over the past two years, according to a new economic report from Biocom, the local industry group. The comprehensive study counted more than 1,700 life sciences companies with a total of 41,937 employees throughout San Diego County in 2011, and says those numbers are expected to grow over the next two years.

—The FDA gave its approval to Cambridge, MA-based Vertex Pharmaceuticals (NASDAQ: VRTX), which has substantial operations in San Diego, for a new drug called Ivacaftor (Kalydeco), developed to treat a rare form of cystic fibrosis. The twice-a-day pill targets about 4 percent of the 30,000 patients in the U.S. with cystic fibrosis.

—Johnson & Johnson’s reorganized R&D operation in San Diego, now known as Janssen Healthcare Innovation, is trying an experiment in innovation by creating an incentive prize challenge. Janssen is offering a total of $250,000 for technology that helps improve care for patients who have just been discharged from a hospital.

—The folks who produce the quarterly MoneyTree report on venture capital funding just released a deeper dive into the details of life sciences investments. The survey shows that VC funding for life sciences increased 21 percent nationwide in 2011, with a total of $7.5 billion going into 785 deals. San Diego ranked third among metropolitan regions in terms of capital invested in the fourth quarter. The top five are Bay Area ($498 million), Boston ($384 million), San Diego Metro ($193 million), NY Metro ($98 million), and Orange County ($97 million

—Optimer Pharmaceuticals (NASDAQ: OPTR) CEO Pedro Lichtinger outlined his plans for expanding the market for the company’s first product, the antibiotic fidaxomicin (Dificid), as a preventative therapy for hospital patients at risk for a nasty intestinal infection called C. difficile. San Diego-based Optimer is planning a clinical trial to prove the drug can help prevent severe diarrhea in patients undergoing bone-marrow transplants.

—A tweet from Bob More of Frazier Healthcare Ventures prompted Luke to delve into the importance of character among life sciences leaders in his BioBeat column. “Politics pretty similar to backing CEO’s,” More said. “Newt may be smart and a good debate guy. But Newt=Smug. Never back smug,”

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Boston startups should be focusing more on creating strategic partnerships with big companies.

An “if we build it, they will come” mindset appears to dominate the Boston startup scene. Too many startups also rely mostly on a pricing and plans revenue model combined with implementing the latest inside sales and marketing 2.0 tools to “get found” while driving demand. A complementary and proactive approach in targeting big companies for strategic partnerships is needed.

Wake up… Most big companies have realized that their current set of technology providers lack the innovation and speed to deliver new competitive solutions. There are new sets of problems that need to be solved that may not have existed even a few years ago. As a result, new innovation programs and budgets have been established, led by senior executives. Their motivation is to fund pilots with emerging technology providers that most times lead to a much larger transaction and partnership strategy. Interesting areas include mobility, social, analytics, and cloud computing.

Take advantage of these customer-funded opportunities as these dollars may also complement your angel and VC funding efforts. Plus, for those leveraging lean startup principles, incorporating a big company “voice” to validate your product development roadmap may commit them to buy additional products and enhancements in the future.

If big companies are approached correctly, senior executives leading innovation programs will make swift decisions. Unfortunately, there are major challenges I see within the startup community to take advantage of these budgets. These include:

• Little focus on proactively targeting big companies. Also, the startup team and their mentors may not possess the sales skills or experience to effectively connect with and relate to big-company senior executives.

• Boston startups are too focused on the product and technology. Big companies are also evaluating their ability to work and collaborate with the startup team. Chemistry is important to these executives.

• You are not the center of the universe. There may be additional value in extending and leveraging existing ecosystem investments.

What I am describing here is not an outdated sales process where the cost to acquire a customer is high and the sales cycles are very long.

Keep in mind that big companies would rather … Next Page »

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When it comes to tech startups—especially in Internet software and app development—San Diego has been adrift in the horse latitudes. That’s the term Spanish mariners had for the waters where the trade winds died out for days and even weeks at a time. Becalmed sailors desperate to gain some headway would heave their horses overboard to reach the New World.

It hasn’t reached that point yet in San Diego, but you would never know that software was once a thriving entrepreneurial community here. Even now, the software sector accounts for more than a third of San Diego’s private technology companies. But as I’ve written previously, it feels as if the local software companies speak different languages. In contrast to the flourishing tech hubs in Seattle, Boston, and New York—not to mention Silicon Valley—San Diego’s software scene is sleepy and indifferent.

Still, there are signs of a freshening breeze.

David Cohen last week at UC San Diego

Scores of new seed-stage startups have begun to emerge throughout the region, including a dozen that just moved into the new EvoNexus incubator in downtown San Diego. These emerging companies are led by young entrepreneurs who view San Diego’s innovation establishment as old-school and irrelevant. They are turning out instead for informal “hackathons” and “meetups.” They tell me they’re yearning for real mentoring by real tech entrepreneurs, and for access to real tech investors who are really investing.

Last week, more than 200 people turned out to hear David Cohen talk at U.C. San Diego about TechStars, the early stage fund and accelerator program for Internet startups that he co-founded with three partners in Boulder, CO, six years ago. Cohen is the CEO, and by any measure, the startup program has been wildly successful.

TechStars enrolled its first 10 Internet startups in 2007, providing as much as $18,000 in seed funding and an intense, three-month mentorship program for each company in exchange for a 6 percent stake. Since then, TechStars has expanded to … Next Page »

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In Michigan, technology spun out of the University of Michigan is firmly entrenched in the startup success stories that get the most press: HandyLab, Accuri Cytometers, and the like. What’s less publicized is the key role Wayne State University’s technology has played in major companies like Asterand and the California-based SciClone Pharmaceuticals.

Wayne State is particularly renowned for its contributions to chemical technology, and, earlier this month, the university hired Harl Tolbert—a former pharmaceutical executive with an extensive business development, licensing, and IP management background—as its associate vice president of technology commercialization tasked with building relationships with startups.

“Once upon a time, I wanted to be a researcher,” Tolbert says. “Then I became drawn more to the business part of science. I made my way out of the lab to a medical clinic in Illinois, and that whet my appetite for understanding how science, medicine, and business intersect.”

Tolbert comes to Wayne State after working in sales and business development at Abbott Laboratories and Pierce Chemical, both located in Illinois. When a job opened up in the technology transfer office at Tulane University, the Louisana native jumped at the chance to return to his home state and raise his children closer to family. Then, about a year later, Hurricane Katrina hit.

“We decided to leave New Orleans,” Tolbert says. “It was really painful, but everything was so uncertain. We didn’t know if we’d be able to rebuild our home or even re-occupy our neighborhood.”

He and his wife had a pact to relocate to the first city that offered both of them a job, and that ended up being Rochester, NY. Tolbert served as the associate director for biological sciences in the University of Rochester Medical Center’s Office of Technology Transfer before landing the job at Wayne State.

Though Tolbert was only slightly familiar with Detroit before accepting his position, he was very familiar with Wayne State, thanks to mentors throughout his career who had intimate ties to the university.

“Wayne State has a reputation for great achievements in chemistry,” he adds.

Tolbert says he plans to increase the school’s efforts to commercialize its technology by pitching both fresh technology and older technology to startups, particularly those in the realm of life science applications that involve human cells or tissue. He’s also seeking ways to develop technology despite the relative lack of funding that university research typically receives, such that the technology is “one or two steps” beyond the earliest stages.

“There’s a need for more bridge funding,” Tolbert says. “That’s true for all universities, and it’s true for Wayne State.”

One advantage Wayne State’s Office of Technology Transfer has is that it’s located in TechTown, the university’s startup incubator and a hub for local innovation. Tolbert imagines that his proximity to TechTown’s entrepreneurs will lead to “a lot of brainstorming in the hallways,” and the chance to not only interact, but keep tabs on companies that are interested in licensing Wayne State’s technology.

“We want to work with more startups in Detroit and the Southeast Michigan region,” Tolbert says. “Entrepreneurs tend to be a little more receptive to early-stage technology. We just have to be creative in how we engage them so that we can help them, and they can help us.”

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After previewing its expansion plans last summer, San Diego’s EvoNexus, the free startup incubator established by the non-profit technology group CommNexus, has opened a newly renovated downtown office space. A dozen early stage companies began moving into the incubator Monday.

CommNexus founded EvoNexus in 2009, when San Diego’s innovation economy was reeling from the Great Recession. The incubator has taken in 14 companies so far, including six that have moved out of the EvoNexus incubator in University City. Office space, utilities, and other services are provided to startups free of charge, and companies leave with no obligations to EvoNexus or CommNexus.

“As far as we know, we’re the only pro bono incubator in the country,” EvoNexus chairman Kevin Hell says in a statement issued late yesterday. “The goal is to grow sustainable tech companies and expand the industry here in San Diego.”

When the EvoNexus incubator first opened in Sorrento Valley, organizers said they wanted to host startups developing advanced communications technologies, including wireless life sciences and smart grid networking.

Since then, CommNexus moved EvoNexus to University City and broadened its criteria. The industry group established the new downtown EvoNexus to host startups that are focused primarily on developing Internet software, Web services, gaming, social networking, and cloud computing technologies. The privately held Irvine Co. made the 15,000-square foot space available to EvoNexus at no cost. The incubator takes up an entire floor of the building at 101 W. Broadway, known locally as the AT&T building.

Hell says he sees parallels in the downtown San Diego locale with San Francisco’s SoMa, the downtown neighborhood South of Market Street that has become a magnet for social media startups and mobile app developers. The nightlife, housing, and amenities available in San Diego’s city center should appeal to young entrepreneurs, Hell says.

CommNexus plans to continue to operate its incubator in University City. The 12 companies in the new downtown space are:

Antengo: Real-time mobile classifieds.

BigSho: Social webcam game show.

Chatmeter: Online reputation management.

Fashioning Change: Shopping experience for eco-friendly apparel.

Saambaa: Social media app for finding things to do.

SwoopThat: Online textbook shopping by course.

TapChow: Cloud-based restaurant experience manger.

Taphunter: Mobile app for locating places that serve craft beer.

UgliApps: Mobile apps focused on food.

Voluware: Saas healthcare information software.

Xpenser: Web-based tracking of business expenses, time, and mileage.

Zambig: Web-based service that provides online outlet for radio ads.

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Here’s a quick update on the agenda for Mobile Madness 2012: Total Mobility, the annual half-day mobile conference we are organizing here at Xconomy Boston. The event is taking place on the afternoon of March 14 at Microsoft NERD in Cambridge, MA. We are looking forward to a packed house and some outstanding talks, discussions, and networking.

I’m pleased to announce a few more startup participants:

—Apperian founder and chief strategy officer Chuck Goldman will join us for a discussion of mobile business strategies, along with Mobiquity founder and CEO Bill Seibel. Goldman is a former Apple exec who leads Apperian’s strategic and business development efforts in enterprise mobile apps. Seibel, for his part, was a founding partner at Cambridge Technology Partners and went on to lead ZEFER, Demantra, and Gumball; he currently leads Mobiquity’s efforts to help businesses develop mobile strategies.

—Fiksu CEO Micah Adler joins us to talk about his company’s approach to marketing mobile apps. My colleague Erin recently wrote about Fiksu’s consumer-facing service, which lets people try out apps from various brands and stores for free.

—Paydiant co-founder Chris Gardner will be on hand to discuss his vision for the future of the mobile wallet—banking, shopping, and e-commerce via your smartphone.

Other confirmed speakers include Jason Jacobs of RunKeeper, Chris Lynch from Vertica/HP, Chuck Kane from One Laptop Per Child, and Seth Priebatsch from SCVNGR. We’ll also have a special panel of Boston’s “mobile mafia,” including Lars Albright (Quattro Wireless, Session M); Mike Baker (Enpocket, DataXu); Tom Burgess (Third Screen Media, Linkable Networks); Jeff Glass (m-Qube, Bain Capital Ventures); and Ryan Moore (GrandBanks Capital investor in Enpocket, Where, and Nexage, now with Atlas Venture).

There are more announcements to come, and I will be posting the detailed agenda soon, so stay tuned. Meantime, you can still grab the early bird rate if you register today.

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San Diego’s StockTwits is developing a bit of a Canadian accent, eh, through a partnership being announced today with Toronto-based Q4 Web Systems, which provides online investor relations services for publicly traded companies throughout North America.

StockTwits is an online social media network that enables traders and shareholders to share their market insights, ideas, charts, and news in real time via Twitter. The startup structures financial and investor-related information from its Twitter feed by stock, user, reputation, and other criteria. StockTwits also enables users to save the stocks they follow to their own portfolios and to limit the comments tweeted about each stock to trusted sources.

As I reported last summer, the four-year-old startup has determined that its chief source of revenue also lies with the investor relations and public relations units of publicly traded companies.

By introducing a ticker tag symbol for publicly traded stocks, $(ticker), StockTwits makes it possible for public companies to sign up for a higher level of StockTwits’ Web service and to “claim” their stock tickers. Once claimed, a company’s IR and PR teams can use the ticker tag to distribute corporate information over the Web in real time.

By partnering with Q4, StockTwits plans to integrate its services with the subscription-based services that Q4 provides its corporate customers. Q4 says its website services include more than 30 IR “best practices” modules that help companies properly provide information and other services to investors and shareholders.

“We’re working with them to make it easier for people to use both of our products,” says Francis Costello, StockTwits’ chief operating officer. He tells me StockTwits has more … Next Page »

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San Diego’s MOGL, a Web-based customer loyalty and rewards program for restaurants and bars, says it has raised $10 million in venture funding to fuel its expansion into San Francisco, New York, and other markets.

The Menlo Park, CA, office of Sigma Partners led the Series B round, which was joined by San Diego’s Avalon Ventures and Austin, TX-based Austin Ventures. That brings total funding for MOGL to $12.4 million, according to a statement from the company. Entrepreneurs Jon Carder, Jarrod Cuzens, and Jeff Federman started MOGL in 2010.

The Internet startup offers its customers multiple incentives for returning to member restaurants and bars, using a mixture of technology, games, and psychology. The incentives include a 10 percent cash back each time a customer returns to eat at participating restaurants. A contest  offers monthly cash prizes to the top three most-frequent customers at each locale. Customers also can automatically donate a meal to someone in need every time they spend $20.

MOGL Homepage Screenshot

MOGL says it provides customer analytics and return-on-investment data for participating bars and eateries. In a statement from the company, Sigma partner Peter Solvik says, “The MOGL team has generated an explosive response from both consumers and restaurant partners, while effectively positioning itself as the most innovative loyalty platform of its kind.”

Since it was launched last April, MOGL has signed up nearly 350 Southern California-based eateries and bars, donated more than 27,000 meals to Feeding America, and has rewarded its members with more than $350,000 in cash back to date.

The company also offers a location-based mobile app for iPhone and Android, so MOGL members can easily locate participating restaurants while on the go. The mobile apps also help customers track their cash rewards and jackpot opportunities, as well as the number of meals donated in their name.

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Serial entrepreneur Angel Gambino has every right to be arrogant—as people with resumes like hers often are—but she’s as down-to-earth and polite as they come.

Sure, a casual question about which local gym she prefers reveals that she’s currently training to be an Olympic soccer-team liaison, the Olympics’ most senior volunteer role and one which oversees every aspect of the team’s participation in the international games, but the answer is delivered in such a gradual, casual manner that it’s hardly bragging. (She’s awaiting confirmation from the Olympic Committee whether she’ll be overseeing the American, English, Italian, Australian, Brazilian, or Argentine men’s team.)

Trust me when I say Gambino’s life is way more interesting than mine and probably yours. She helped develop Gameplay.com, an early gaming site that eventually had 900 employees in nine countries; was instrumental in helping to popularize the social network Bebo, which was sold to AOL Time Warner in 2008 for $850 million; helped oversee the BBC’s expansion into mobile, broadband, and on-demand platforms; and helped launch social and video-on-demand platforms for Viacom channels such as MTV, VH1, and Comedy Central.

Gambino is still a co-owner of Sonico, the third largest social network in Latin America—Gambino describes it as “the Facebook of Latin America before Facebook became the Facebook of Latin America”—as well as Spoonfed Media, a popular website that directs Londoners to upcoming arts and entertainment events.

So what the heck is she doing in Detroit?

Gambino and her partner, Scott Griffin (more on his story later), purchased a massive building on Rosa Parks Blvd. for $270,000 in September, which they plan to turn into retail, restaurants, and space for local startups, the first step in a plan to further revitalize the Corktown area so it attracts not only the suburban visitors that are already coming in droves to eat at the neighboring Slow’s Bar-B-Q, but also to send the message to entrepreneurs around the globe that Detroit is the place to be.

“Detroit is a city of tremendous opportunity—I don’t know any other cities like it in the world,” Griffin says. Responding to the question of why two people as worldly as he and Gambino would choose Detroit as their base of operations, Griffin says, “I wonder why there aren’t more of us here already. I don’t understand why there aren’t a thousand of us here competing for these deals.”

Gambino was actually born in Detroit, though she spent her formative years in the suburbs outside of the city. Even in her youth, she says it was obvious to her that there were a lot of things lacking in Detroit.

“I knew Detroit was famous for sports and music, but not much else,” Gambino says. … Next Page »

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It’s that outlook time of year, and Mark Heesen, president of the National Venture Capital Association (NVCA), was in San Diego earlier this week, talking about the 2012 outlook for venture capital. Today he’ll make a similar presentation to the New Jersey Technology Council. Next week,  John Taylor, the NVCA’s director of research is set to talk in Florida about the 2012 outlook.

Heesen began his presentation in San Diego by saying, “Be prepared for a roller coaster ride here, because that’s where we’ve been for the past year—and that’s where we’re going.”

In a conversation with Xconomy yesterday, Heesen talked about some of the broader trends he’s charting throughout the United States. Here are some of the takeaways from our talk, and from Heesen’s presentation in San Diego:

—The VC industry continues to contract. Venture capital investments in U.S. startups peaked in 2000, when VCs sank $99 billion into emerging companies of all kinds. There were 1,022 venture capital firms at that time, and they were collectively managing $220 billion worth of invested capital. In 2010, VCs invested more than $20 billion into startups of all kinds. The number of VCs had plunged by almost 55 percent—to 462 VC firms with $177 million under management.

—VCs are raising more capital from their limited partners, but it isn’t enough to sustain current investment levels. In 2011, U.S. venture firms raised a total of $18 billion. That was up significantly from the $14 billion that VCs raised in 2010—but it falls $10 billion short of covering the $28 billion that VC firms invested in 2011. As a result, Heesen says he expects venture investments in U.S. technology and life sciences companies to decline in 2012.

—A handful of VC firms accounted for … Next Page »

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Mark Lowenstein has made some pretty bold statements about what’s going to happen in the wireless industry this year. More mergers and acquisitions among mobile operators. Same goes for the handset makers. Mobile payments won’t take off just yet. And enterprises may have jumped the gun on tablets.

Lowenstein, a Verizon Wireless veteran and now managing director of the Boston-area consultancy Mobile Ecosystem, dishes out insights like this via his regular e-mail newsletter on the mobile industry, but I wanted to dig in with him a bit more deeply on what these big changes mean for startups and other innovative companies working in Boston and beyond.

Plus, the Xconomy newsroom has been a bit buzzy with mobile news lately, after we just announced our fourth annual half-day forum on the subject, Mobile Madness 2012 on March 14.

Lowenstein, an Xconomist, pinpointed a couple of different facets of mobile technology that aren’t necessarily new, but that are maturing and hitting new stages. Read on for those, and some of the startups around the country that are driving these trends.

—Enterprise Mobility: Big companies have been scrambling to put a mobile face on their business, and startups have been sprouting up or changing their approach to support them. “It’s not just about mobile enabling what they’re already doing,” says Lowenstein. “It’s about how it can be an additional potential revenue stream for them.” In fact, just this morning Framingham, MA-based Staples, one of the world’s largest retailers, announced it would be setting up a new e-commerce innovation facility in Kendall Square, with mobile as a big focus.

Businesses that need to build consumer-facing, brand-specific applications will continue to turn to mobile strategy and consulting firms to do the heavy lifting.

And companies that have previously developed individual applications for enterprises are now starting to sell the tools that allow companies and brands themselves to move much of their activity to the mobile front. That includes Boston-area firms like Raizlabs, Apperian, Modo Labs, and most recently, Verivo Software (formerly known as Pyxis Mobile).

—The App Marketplace. Speaking of apps, enough is enough. It’s been about four years and around half a million apps since Apple introduced its iTunes app store. “It’s been terrific, but one gets the sense that it needs to get to the next and more mature stage,” says Lowenstein. Meaning, a majority of apps don’t have a company behind them, don’t get updated, and don’t really make money. “They’re a fad, a fly … Next Page »

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The unsolicited $5.7 billion offer that Roche made for Illumina will no doubt dominate San Diego’s biotech news for weeks to come. We have it and more.

—Switzerland’s Roche offered $5.7 billion, or $44.50 a share, for San Diego-based Illumina (NASDAQ: ILMN in a hostile bid disclosed yesterday. Roche’s bid to stake a claim in genetic diagnostics by acquiring the market-leading maker of DNA sequencing instruments would be the Swiss pharma giant’s biggest deal since its $46.8 billion buyout of Genentech almost two years ago. Roche is the world’s biggest maker of cancer drugs, which suggests its quest for Illumina represents a significant move to base cancer treatments on each patient’s genome.

—Venture capital investors sank $4.73 billion into 446 biotechs nationwide in 2011, according to the MoneyTree report from the National Venture Capital Association, PwC, and Thomson Reuters. But as Luke pointed out in his BioBeat column, there is an alarming drop in support for early stage life sciences startups. Only 153 biotech and medical device startups got their first round of financing in 2011, the lowest amount of seed investment activity in 15 years.

—At an Xconomy dinner discussion, former Amira Pharmaceuticals CEO Bob Baltera said insufficient access to capital is the biggest driver for decision-makers on both sides of biotech-pharma partnerships. So what are some other key factors? We asked some of San Diego’s life sciences leaders to explore the question in an “on the record” dinner discussion late last year.

—San Diego’s Sequenom (NASDAQ: SQNM) completed its secondary public offering, raising roughly $62 million in gross proceeds (before underwriting costs) in the sale of 14.95 million shares, including additional allotments granted to underwriters. Sequenom said it plans to use the net proceeds for … Next Page »

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Detroiters often grumble about the relative lack of shopping options downtown compared to other cities of similar size. Sure, there are boutiques here and there, as well as a handful of stores in the Renaissance Center and the Millender Center, but there is no Urban Outfitters; no American Apparel; no Macy’s.

Somerset CityLoft, a pop-up shop along Merchant’s Row featuring outposts of stores found in the suburban Somerset Collection mall, drew enthusiastic reviews but it was hard to get excited about something so fleeting—CityLoft was only open during part of the summer and again around the holidays.

Downtown shoppers now have a new option: Virtual retail in formerly vacant storefronts at 1520 and 1528 Woodward. Quicken Loans, which also had a hand in opening Somerset CityLoft, has partnered on the new endeavor with Jeff Freedman, a Detroit native and the owner of Resultco, along with its umbrella companies Fathead and Bedrock Real Estate.

Instead of racks of actual merchandise, the group installed product images along with corresponding QR codes in buildings’ windows. Shoppers can stroll past at any hour of the day or night, pull out their smartphones, and scan the codes for more product information or to buy the items. As of now, custom watches from Detroit-based Watchwear are on offer, but Mullen says that the storefronts will feature products from Shoebuy, Clothesbuy, Bagbuy, and more in the coming weeks.

“As we build out our properties, we wanted something immediate,” says Bedrock real estate developer Dan Mullen, noting that his company has acquired nine buildings along Woodward between Jefferson and Grand Circus Park. “With the spiderwebs and the rats—ok, rats are an exaggeration, but there’s no question these vacant storefronts are an eyesore. We didn’t want them sitting there and collecting dust.”

Mullen says that though shoppers won’t be able notice, there is construction going on behind the virtual retail shop’s windows as Bedrock continues its plan to revitalize downtown Detroit. When construction is complete, Bedrock will simply pack up the signs and move the virtual retail operation to another of its nine buildings.

“Our thought was, let’s activate this street now,” Mullen adds. “We’re hoping we inspire real, lasting retail.”

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