Ryan McBride wrote:

Pilates is famous for shaping up peoples’ buttocks, tummies, and thighs. But what can the popularity of this fitness phenomenon and the market for health products do for investment portfolios? Cambridge, MA-based Lighter Living, which operates a health and fitness website that features Pilates expert and company founder Marjolein Brugman, has raised $3 million in an equity round of financing, according to an SEC filing.

Brugman, who appears to have pioneered an aerobic version of Pilates called AeroPilates, is listed in the regulatory filing as an executive and director of Lighter Living. There’s also a big name in venture investing involved with the firm: Michael Greeley, a founder and general partner of Boston-based venture firm Flybridge Capital Partners, who is listed as a director of Lighter Living. Neither Brugman nor Greeley was immediately available for comment this morning, but a spokeswoman for Flybridge confirmed that the firm is backing the company.

At first glance Lighter Living—which sells fitness and wellness products and offers health tips and insights from Brugman on its website—doesn’t seem like a typical bet for Greeley. However, he’s always told me that he is interested in businesses in which healthcare and information technology intersect. Previously, his interest in healthcare and IT has been manifest in investments he has led for Flybridge in companies such as Bedford, MA-based MicroCHIPS, a developer of micro-devices for medical uses, and business software firm BlueTarp Financial, of Portland, ME.

Yet Lighter Living does address a huge market demand for products that help people look and feel youthful, and there is an emerging trend of interest in this market among venture capitalists. Polaris Venture Partners is backing Cambridge, MA-based Living Proof, a provider of hair-care products based on advances in polymer science at MIT and other research institutions. Investments in the likes of Living Proof and Lighter Living could provide a boost for both consumers’ looks and venture portfolios’ outlooks.

Flybridge’s investment in Lighter Living is “building on [Brugman's] success in the healthy living market,” said Kate Castle, a spokeswoman for the venture firm. She said that Brugman has sold more than $500 million in healthy living products on the TV shopping channel QVC over the past 12 years.

Lighter Living is planning an official launch in 2010, Castle said.

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Dealmakers appear to be getting their business done before the week of Thanksgiving—because we’ve seen a decent stream of deal closings involving Boston-area life sciences and tech companies over the past week or so.

—Framingham, MA-based Punchbowl Software, which operates the party planning website MyPunchbowl.com, said it acquired technology assets of a group vacation website called I’m In. Punchbowl founder and CEO Matt Douglas provided details on why the transaction made sense for his startup.

—After months of operating quietly, seed-stage venture fund Founder Collective officially debuted last week. Eric Paley, a managing partner and co-founder of the firm, told us why he and other software entrepreneurs came together to form the new venture outfit, which has offices in Cambridge, MA and New York City. Here’s a hint: They were a bit frustrated with the status quo in the venture industry.

—Fate Therapeutics, the San Diego-based biotech startup focused on developing techniques that make stem cell research practical for the pharmaceutical industry, reeled in $30 million in a Series B round of venture financing. Kirkland, WA-based OVP Venture Partners led the new round of investment in Fate, which was founded by top academics at Harvard University, Stanford University, The Scripps Research Institute, and the University of Washington.

—ImmunoGen (NASDAQ:IMGN), a Waltham, MA-based biotech firm, reported this week that the firm sold a second license to its technology—which is for linking targeted antibodies to cell-killing molecules—to industry giant Amgen (NASDAQ:AMGN) for $1 million upfront, plus potential milestone payments.

—Corindus, a Natick, MA-based startup developing a robotic system for implanting vascular stents, collected $5.3 million of a planned $10 million in venture dollars, according to a filing with the Securities and Exchange Commission.

—Cambridge -based Ligon Discovery found $1 million in a seed round of financing from incTANK Ventures, with plans to validate its small molecule microarray system for drug discovery that was developed at Harvard. The company was founded by folks from Harvard Medical School and the Broad Institute of MIT and Harvard.

—We spotted Angus Davis, a co-founder of Microsoft’s voice-based Internet search subsidiary Tellme Networks, at Polaris Venture Partners’ Dogpatch Labs recently and wondered what he was up to. It looks like he’s been working on a new Providence, RI-based startup called Swipely, which quietly swept up a cool $1 million from First Round Capital.

—Jealous? Highland Capital Partners, the Lexington, MA-based venture powerhouse, closed its eighth fund, worth a whopping …Next Page »

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We hope to make this a regular feature in our Xconomy cities. It’s a look at small financings of private companies in tech, life sciences, and cleantech. These are deals in the roughly $100,000 to $1 million range, and they’re increasingly where the action is for local entrepreneurs, yet they’re often harder to track than the bigger deals we tend to report on.

And there were at least 12 of these smaller financings in the Northwest in October (see table below), according to ChubbyBrain, a New York-based information services company tracking VC, angel, and other investments in private companies. ChubbyBrain gets its data from regulatory filings, user submissions, and other sources, and this is the second monthly installment of “under the radar” deals in the Seattle area (you can see the previous deals for September here). The data didn’t include the investors or the stage of financing.

A few quick observations: Like the previous month, most of the financings were in Washington (7 out of 12), but a significant number (5) were in Oregon. Most were equity deals (7), with the rest (5) being debt financings. The majority of financings (9) were in software, Internet, or tech, while a much smaller number (3) were in life sciences and healthcare, and no cleantech or energy deals made the list.

If nothing else, these lists are a cool way to hear about emerging startups we otherwise wouldn’t know about. For example, I’ve heard of Teranode, Nearlyweds, and 1000Museums before, but Zapproved and Intellisist are completely new to me.

Here are the 12 “under the radar” deals from last month:

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It wasn’t so much the predictions as the discussion that was most interesting at last night’s annual predictions dinner, organized by the Washington Technology Industry Association. Will Twitter be acquired in 2010, and why? Who will have the dominant cloud computing platform in the next couple of years? What kind of startup are you looking to build or finance, and which areas are you staying away from?

A panel of Seattle-area tech entrepreneurs and investors gamely took the bait and had some lively exchanges over the course of an hour. OK, these guys all know each other, and we’ll take what they say with a grain of salt since it’s a public forum—but here were some of the most interesting points they made. (You can read more comprehensive recaps of the panel on Brier Dudley’s blog at the Seattle Times, and soon on TechFlash by moderator John Cook.)

The panel was split 3 to 2, with the narrow majority guessing Twitter will get bought next year. Andy Sack of seed-stage fund Founder’s Co-op predicted Twitter will make more money than Facebook in 2010 (surprising, given the current disparity in the other direction). Glenn Kelman, the CEO of Redfin, an online real estate firm, said Twitter should charge for search (as it has begun to do in partnerships with Google and Bing). Kelly Smith from Curious Office and the startup Pressplane argued that Twitter could be “absorbed by a big company,” but “it’s going to go nowhere.” By the end of the evening, Sack was predicting that Microsoft would buy Twitter next year.

There was a consensus that 2010 could be a big year for acquisitions. Bill Bryant of Draper Fisher Jurvetson boldly predicted that Amazon will buy Netflix, Blockbuster, and Hulu, while opening brick and mortar “Amazon media stores.” Greg Gottesman from Madrona Venture Group said Cisco might buy EMC (for VMware) and Seattle-based F5 Networks, while Microsoft might buy Research In Motion, the maker of the BlackBerry smartphone. Sack predicted Adobe would pick up Seattle photo-editing startup Picnik. Rupert Murdoch (News Corp.) would buy Seattle’s Cheezburger Network, and someone would buy Redfin.

Looking back on 2009 for a minute, the big deals that were questioned by the panel included Adobe’s acquisition of Omniture (Gottesman said it just didn’t make sense strategically) and …Next Page »

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Natick, MA-based Corindus has corralled $5.3 million of a proposed $10 million round of equity financing, according to an SEC filing. The firm is developing a robotic system that helps surgeons control the position of guidewires in veins in procedures to implant vascular stents, according to the firm’s LinkedIn profile. A call to company CEO David Handler was not immediately returned today, and it’s not stated in the SEC filing who participated in the financing. Prior to this financing, the firm raised $12.8 million in a Series B financing in spring 2008, according to a story I wrote about the deal for Mass High Tech.

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Ligon Discovery reported today on its website that it has raised $1 milllion in seed financing from incTANK Ventures. The Cambridge, MA-based startup says it uses a small molecule microarray system developed at Harvard University to discover drugs, and the drug-discovery technology has already been put to work at the Broad Institute. The company founders include Benjamin Ebert of Harvard Medical School, Angela Koehler of the Broad Institute, and company CEO Patrick Kleyn, who was previously director of scientific planning at the Broad. As part of the financing, IncTank Ventures general partner Christian Bailey is joining the board of directors at Ligon, according to the company.

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Braemar Energy Ventures, a venture firm focused on investments in the cleantech sector, has named Jiong Ma a partner of the firm, according to a Mass High Tech report. She was previously a principal at the firm, which has offices in Boston and New York City, according to its website. Braemar’s portfolio includes such Boston-area cleantech companies as A123 Systems (NASDAQ:AONE), EnerNOC (Nasdaq:ENOC), and Verenium (NASDAQ:VRNM).

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Seattle-based venture capital firm Maveron has been in the news a lot this month. There have been reports about its latest stealth startup, which is a new type of e-commerce play. Another report from VentureWire said Maveron will be selling its shares in Motley Fool—a deal that will generate cash for Maveron, which led a $26.5 million financing of the online investing website in 1999. And then, just yesterday, I got a press release about Maveron expanding to San Francisco and Silicon Valley.

The VC firm, co-founded by Howard Schultz of Starbucks fame, is used to this sort of attention. But the San Francisco news was a bit confusing to me, because Maveron has been active in the Bay Area for a long time. As usual, the interesting stuff is in the follow-up. I had a chance to connect yesterday with Dan Levitan, a fellow co-founder of Maveron and the mastermind of the firm’s consumer-focused investment strategy. Besides the new San Francisco office, I also asked Levitan about the Seattle e-commerce startup his team is currently building; his outlook and themes in the consumer tech space; and his first fateful meeting with Schultz back in the early 1990s.

First, some basic stats. Maveron was founded in 1998 by Levitan and Schultz, and is best known for its early investments in eBay, drugstore.com, Shutterfly, and Cranium. Its current portfolio companies—there are 22 active around the U.S.—include Potbelly Sandwich Works, Pinkberry, LiveMocha, and Altius Education. The venture firm has about $750 million under management.

Levitan explained that opening Maveron’s San Francisco office has been a two-year process, but it doesn’t signify any shift in the firm’s geographic focus. “I don’t see this announcement as anything more than opening an office where we’ve already done business,” he said. “We’re one firm with two offices.”

The San Francisco office is headed by Amy Errett, a veteran of Olivia.com and E*Trade, who was announced as a Maveron partner last year. She is joined by new principal Ben Choi, who was previously with Storm Ventures, In-Q-Tel, and RRE Ventures. As Levitan puts it, instead of Errett flying up to Seattle four times a month, she’ll fly up three times a month (and the Seattle team will fly down the fourth week).

But Levitan emphasized that he’s looking in his own backyard for new investments as much as ever. “Seattle is an economy and region that’s very rich with groundbreaking, innovative consumer companies,” he said, pointing out obvious examples like Starbucks, Nordstrom, Amazon, and Costco. One less obvious company he mentioned was online real estate broker Redfin, which isn’t in …Next Page »

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Drug development programs got extended at two San Diego life sciences companies, while others had some good news on the fund-raising front. We wrap it all up for you here.

—Fate Therapeutics, a startup working to supply “industrialized” stem cells for the pharmaceutical industry without using embryos, said it raised $30 million in venture capital. That brings the total amount raised by the San Diego-based company to about $50 million since its inception two years ago.

—Cadence Pharmaceuticals (NASDAQ: CADX) said the FDA has delayed its review of the San Diego company’s intravenous pain reliever by three months, to Feb. 12. Cadence provided additional data to the FDA after an advisory panel raised concerns about liver damage from excessive doses of acetaminophen. But Cadence said it remains confident it will win FDA approval of its drug, which contains acetaminophen.

—Carlsbad, CA-based Isis Pharmaceuticals (NASDAQ: ISIS) and its Big Pharma partner, Genzyme (NASDAQ: GENZ), have extended the timeline for their much-anticipated cholesterol-lowering drug by nearly a year. The companies reported encouraging results from a clinical trial, but noted that four out of 34 patients saw their liver enzymes increase to three times normal, a sign of potential liver damage. The companies plan to tinker with the dose of the injectible drug in future trials.

—San Diego-based NextImage Medical, a developer of a Web-based system for scheduling and managing diagnostic imaging services, reporting raising $5 million in a venture round led by Chrysalis Ventures of Louisville, KY.

—San Diego-based Altair Therapeutics, a company developing inhalable drugs to block inflammatory proteins involved in asthma and other respiratory diseases, has closed on the second part of a Series A venture financing, bringing the total amount raises this year to $17 million.

—San Diego-based Cyntellect, which makes work stations used by biotechs for cell analysis, purification, and processing, raised $15.5 million so far in a secondary round that aims to raise a total of $18.6 million, according to a recent regulatory filing.

—GenVault, a Carlsbad, CA-based company that markets dry-storage technologies that allow scientists to store biological samples at room temperature, said it expects to break even by the end of next year. The startup has raised about $32 million so far.

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Seattle-based Voyager Capital has participated in a $5 million investment in 1020, the San Francisco developer of Placecast, a location-based advertising and marketing platform, according to a report in TechCrunch. Quatrex Capital and Onset Ventures also participated in the Series B funding, which will be used to accelerate Placecast’s technology development. Placecast’s algorithms combine data across the Web, mobile, e-mail, and Wi-Fi to try to maximize relevance for advertisers and publishers. In an interview with Xconomy last year, Voyager co-founder Enrique Godreau mentioned 1020 as an example of an intriguingly mainstream mobile startup.

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Managing a venture fund is hugely different from running a startup. Eric Paley told me that last year at this time his primary responsibility was at dental imaging firm Brontes Technologies, the MIT spin-off that he co-founded and where he had served as general manager after its sale to technology giant 3M (NYSE:MMM) in 2006. Nowadays, as managing partner and co-founder of new seed fund Founder Collective, his much broader focus includes meetings with a whopping 30 entrepreneurs a week, he said.

Early this month Paley’s firm had an official launch after closing a first fund of about $40 million to invest in seed-stage startups, even though reports about the firm surfaced in June after its initial SEC filings became public knowledge. The firm is made up of a group of successful entrepreneurs who have been backing each other’s startups for ages before coming together as Founder Collective. David Frankel, the firm’s other managing partner along with Paley, was a seed investor in Brontes as well as partner Chris Dixon’s startups SiteAdvisor and Hunch, for example. Their experience as entrepreneurs who have raised venture capital and reached successful exits, along with their compelling investment strategy, could help them succeed in the struggling venture industry.

Founder Collective, which has offices in Cambridge, MA, and New York (where Frankel is based), is taking a much different tack than many funds have taken over the past decade. Paley says that the vast majority of funds closed over the past 10 years have been more than $100 million, while most of the funds were less than that in the previous decade. But the big knock on the venture industry is that it’s done a poor job of returning capital and returns commensurate with their risk profile to their limited partner investors. And large funds often aim to invest big amounts of capital ($10 million or more) in their portfolio companies, even when companies don’t really need that much money, Paley says. Founder Collective’s first fund is a lean $40 million or so, and that money is intended to be invested in capital-efficient businesses that aren’t taking on more investment capital than is needed to achieve their goals. Indeed, we’re seeing this movement toward smallish investments in lean teams, at least in software/tech, all around the country.

Another big downside of a startup raising more venture capital than it requires to execute its plan is the dilution of ownership for the entrepreneurs who founded the company. “We really created the fund out of frustration that there wasn’t a really good answer for the capital-efficient business in the early days to achieve major milestones and increase the value of the company before giving so much of it away to investors,” Paley said.

There are no banker-turned-venture capitalists at Paley’s shop. Many of the partners maintain operational roles at startups they’ve co-founded. Dixon, a founder of Web security firm SiteAdvisor (acquired by McAfee), is full-time CEO of his firm Hunch that provides an online decision-making tool. Also, Micah Rosenbloom, who co-founded Brontes with Paley, is now the general manager of the Brontes business for 3M. (Here’s a full list of the the Founder team on the firm’s website.)

The investment philosophy at Founder is to back startups led by committed entrepreneurs. And though Paley said the firm has no stated limits on sectors or geographic areas in which it invests, the firm will most likely invest, as it has done so far, in …Next Page »

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On May 18th of 2009, I signed the papers to legally incorporate my first company. Three weeks later, I graduated from MIT with my BS in biological engineering. Fast forward, and after 10 months of working on the venture, it was decided to not continue.

After failing to get the outcome the team had hoped for, some questions loom: did I make the right decision to jump into the entrepreneurial arena so early in my career? Is it generally a good idea to start a company right out of college?

Before I answer these questions with the benefit of hindsight, I’d like to first take you through the process that led to my decision to just go for it.

During the year prior to making this decision, I had spent a lot of time thinking about what I would do after graduation. I knew I wanted to be a part of the entrepreneurial community, so I began learning all I could about the entrepreneurial process. I read everything I could get my hands on, I talked my way into relevant MBA courses at MIT’s Sloan School of Management, I did projects for startups and venture funds, and I sought advice from members of the entrepreneurial community.

I received a variety of opinions on the best route for getting into the land of startups. Here are the three most common views, along with my brief analysis of each:

Go get a job. Learn how real business is done first. This is the safe advice, which is why it is the most prevalent. By getting work experience, you get a chance to really develop your network, expertise, and understanding of problems in a specific industry. However, working in a mature business isn’t anything like a startup.

Go work for a startup. “Startup” work environments, of course, vary heavily. Some startups are a couple of guys working out of their apartment trying to find a way to make some revenue. Others are more like developed companies, with office space, hours, and managers.

At the time, to me, joining a later-stage startup didn’t seem all that different from getting a job at a more mature company. Joining a smaller band of warriors setting out on the start-up road would have been difficult. In the early stages, such efforts mainly need engineers to get a prototype built. I knew how to code, but programming wasn’t my forte. All in all, this wasn’t a very good option in my eyes.

If it feels right, go do it. The negatives for starting a company immediately after school are the lack of experience, network, credibility, and money. But, there are many positives:

• Access to a lot of help. I find the entrepreneurial community to be incredibly supportive, with lots of vibrant, experienced people happy to help students. I had access to tons of great people through the MIT and Boston communities. I talked with professors, cold called and emailed alumni, and just found a way to get in touch with people. Not everyone would respond, but those who did were extremely helpful.

• Low opportunity cost. You aren’t walking away from a high-paying job in order to attempt a startup, so you have little to lose financially if it doesn’t work out.

• Low responsibility. By this I mean you …Next Page »

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San Diego’s NextImage Medical, Inc., which has developed a Web-based system for scheduling and managing diagnostic imaging services, says it has raised $5 million in Series A funding in a round led by Chrysalis Ventures of Louisville, KY. Liz Griggs founded NextImage Medical last year as a way to provide high-quality, low-cost radiology services, either through insurers, self-insured employers, or direct-to-consumer. A statement from NextImage Medical says Griggs previously was the founder of New Jersey-based One Call Medical, a radiology preferred provider organization (PPO) that was sold in 2003 for $115 million.

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I had an opportunity to sit down recently (along with several other journalists) for an informal chat with Ellen Pao, a partner at Kleiner Perkins Caufield & Byers and a member of the famed Menlo Park, CA, venture firm’s GreenTech investment team.

Pao was in town to be the keynote speaker at the inaugural Cleantech San Diego Showcase, an event the non-profit industry group intends to hold four times a year as a way of calling attention to emerging green technologies and the local companies developing them. Pao provided an overview of KPCB’s GreenTech team, which consists of 20 partners in the United States and China. The firm has invested about $680 million over the past five years in nearly 50 startup companies, most of which remain in stealth mode.

Pao was gracious, but not especially forthcoming. For example, she told us that KPCB’s greentech investments include funding San Diego-based V-Vehicle Co., which announced plans earlier this year to build a new line of “environmentally friendly and fuel-efficient” cars in Northeastern Louisiana. The green aspect of the V-Vehicle’s design apparently figures in the startup’s request for a $250 million low-interest loan under the Department of Energy’s Advanced Technology Vehicle Manufacturing program. But V-Vehicle has not explained publicly how or why its car is eco-friendly, which has led to conflicting media reports (with some describing it as an electric vehicle). But Pao declined to explain why V-Vehicle is green, saying KPCB doesn’t talk about portfolio companies that are still in stealth mode—even though partners John Doerr and Ray Lane participated in a news conference that Gov. Bobby Jindal of Louisiana held in June to announce the state’s support for the project.

Pao said KPCB’s cleantech investments are divided among startups that are focused in a variety of green categories, including energy efficiency, cars and transportation, batteries (especially companies developing new energy storage capabilities for electric utilities), renewable energy, and “carbon management and sequestration,” i.e., technologies for preventing carbon dioxide from wafting into the atmosphere by capturing the gas and piping it underground.

“There’s a lot of passion around trying to solve the global warming problem,” Pao said. “We’re looking, though, for big solutions. We have some projects, and we think it’s a big opportunity once there is a price on carbon.” She was referring to a “cap and trade” proposal put forward by the Obama Administration that would set strict limits on pollution that causes …Next Page »

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I sat in on a good venture capital panel yesterday at Mobile Northwest 2009 in Seattle. No huge arguments or chair throwing to speak of (we’ll see what we can stir up at the next few Xconomy Forums). But some solid and useful observations from Geoff Entress of Voyager Capital, and also a prominent Seattle-based angel investor; Adrian Smith of Ignition Partners in Bellevue, WA, an expert in telecom and wireless; and Puneet Tandon of Bellevue-based T-Mobile USA, who is looking to sign partnerships with top entrepreneurs in digital media and social networking. (You can also see some comments from mobile VC Tom Huseby’s keynote here.)

The panel was moderated by Tricia Duryee, the Seattle-based correspondent for mocoNews, a website that covers wireless telecommunications. Here are my quick “top three” takeaways from the discussion of the local mobile industry:

1. The panic may be over, but caution rules. Entress says he’s added nine companies to his portfolio this year, out of a total of 32 he’s involved in (and six mobile firms, including TravellingWave, Swype, Dashwire, and Treemo). “We’re definitely not out of the woods yet,” he said. “But 2010 might be a good year for selling companies.”

2. It’s not all about the iPhone. Entress and Smith pointed out that Apple has only 17 percent of the smartphone market, so there’s plenty of opportunity on other platforms, like the BlackBerry and devices that use Windows Mobile. “Apple has a huge amount of mindshare,” Smith said, “but the critical thing is the development environment around [mobile applications].” Tandon agreed, saying, “Barriers to doing business with us [carriers] perhaps have been lowered.” Entress stressed the importance, especially for startups, of trying to avoid “getting locked into any one carrier, handset, or operating system.”

3. Watch advertising, input technologies, and connected devices. Tandon pointed out that by sometime next year, there are projected to be 3.3 billion Web-connected devices, and 70 percent of them will be connected via wireless operators. That means carriers will be willing to pay to know “who are the social influencers in your subscriber base,” he said. Smith and Entress said Google’s $750 million acquisition of AdMob signifies that mobile advertising is here to stay—but that the deal was the “first one out” (like YouTube for video), so don’t look for anything near that sort of valuation again. Entress added that he’s working with a number of startups selling new ways of inputting text on mobile devices (using speech recognition, touch-screen methods, and so forth). For all our fancy gadgets, it seems we still struggle to communicate.

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Just when I thought venture deals, especially for software and tech companies, had headed south for the winter (or longer), the Northwest erupted with a slew of financings in the past week.

—But first, some serious biotech. Kirkland, WA-based OVP Venture Partners led a $30 million Series B round for Fate Therapeutics, a San Diego-based stem cell company with ties to the University of Washington, as Luke reported. Existing investors Arch Venture Partners, Polaris Venture Partners, and Venrock Associates also participated in the funding, as well as three strategic corporate investors—Astellas Venture Management and Genzyme Ventures were named.

—Seattle-based DocuSign, a maker of software to automate and control the process of electronic signatures, received a strategic investment from Second Century Ventures, the VC fund of the National Association of Realtors. The funding amount was undisclosed, but the money will be used to accelerate and extend DocuSign’s efforts with real estate customers.

—Beaverton, OR-based Avnera pulled in an $8 million equity round from undisclosed investors, according to a regulatory filing. The company’s previous investors include Bessemer Venture Partners, Redpoint Ventures, Jafco Ventures, Intel Capital, and DAG Ventures. Avnera was founded in 2004, and designs novel chips for wireless audio applications.

—Seattle stealth startup Doxo raised $5.25 million in equity financing, according to a regulatory filing and media reports. The investors were not disclosed, but David Feinleib of Mohr Davidow Ventures was listed on the SEC form as a director.

—Bellevue, WA-based Enroute Systems, a developer of software that helps companies manage their parcel-shipping logistics, closed a Series A funding round worth $810,000 from Keiretsu Forum, Zino Society, Puget Sound Venture Club, and angel investors. Next up, Enroute is looking …Next Page »

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San Diego’s Global Analytics Holdings says it has raised $10 million of a targeted $14 million round that consists of equity investments, options, and rights to securities, according to a recent regulatory filing. The company provides consulting services for business customers and specializes in developing software for statistical analysis, predictive modeling, and neural networks.

The filing indicates the capital is being raised in connection with a merger, acquisition, or exchange offer, but founding CEO Krishna Gopinathan did not respond to a call or e-mail seeking further information. According to the Global Analytics website, Gopinathan was the primary inventor of Falcon Fraud Manager, a neural-network technology developed at San Diego-based HNC Software (now part of Fair Isaac) that is used to protect most credit cards worldwide.

Global Analytics has been operating at least five years and has more than 100 employees, according to its website. A number of key executives at Global Analytics, including the executive vice president of analytics, vice president of products, and vice president of software development, are former HNC employees.

Last year, Global Analytics named Larry Rosenberger, the former CEO of Minneapolis, MN-based Fair Isaac, to its board of directors. The company also noted that Rosenberger and his wife Diane invested in the San Diego startup. Peter Rip, a general partner at San Francisco’s Crosslink Capital, also is on Global Analytics’ board, although Crosslink does not identify Global Analytics as a portfolio company.

Global Analytics also has formed a strategic partnership with Hewitt Associates, the Illinois-based human resources and outsourcing firm, and has been working on what it calls “the objective quantification of the value of human capital investments.” The company says it has been working with Hewitt in recent years to pioneer development of comprehensive models that tie such human resources metrics as talent attraction, retention, and engagement to shareholder value, creating what Hewitt calls its Human Capital Foresight.

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Seattle-based DocuSign announced today it has received a strategic investment from Second Century Ventures, the VC fund of the National Association of Realtors. The amount was undisclosed, but the cash will be used to speed up and extend DocuSign’s efforts with residential and commercial real estate customers. DocuSign was founded in 2003 and makes software to automate and control the process of electronic signatures.

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Tom Huseby says he’s finally able to go home and not worry about seeing his family’s savings stuffed under his mattress. “The panic is over,” he says. “All of a sudden, things are getting a lot better. It doesn’t feel much better now, but it is.”

Huseby, a noted Seattle-based venture capitalist with SeaPoint Ventures, Oak Investment Partners, Hunt Ventures, and Voyager Capital (and the Godfather of what we’ve been calling the “Qpass mafia”), was giving his 30,000-foot view of the economic landscape and VC market at today’s Mobile Northwest 2009 conference in Seattle. He also drilled down into some of the most pressing challenges in the mobile space, as well as what the startup opportunities are. Just a few highlights here:

“Unemployment is going to slow growth across any consumer business. If you’re in mobile, I hate to tell you, but you’re in the consumer business. I do think there will be liquidity in mobile startups,” Huseby says. “Most startups are going to have to earn it the old-fashioned way, they’ll have to grow over a long time. You’re going to have to survive during a roller coaster ride. Every single company will have to go rushing to the bottom, and then do the slow, clanking ride to the top.”

In terms of startup opportunities, it helps to think in terms of what wireless carriers need. Huseby calls himself “fairly carrier-centric.” As he puts it, they are big customers that are predictable (once you understand them) and they generate huge amounts of cash. He laid out the top three challenges for carriers today—absolutely critical to understand if you’re an entrepreneur trying to get their attention with a new product.

—Bandwidth. There’s “tremendous pressure on carriers” to provide more bandwidth to support people’s exploding need for data connectivity wherever they go, Huseby says.

—Costs of bandwidth. “Oh my God, how are you going to pay for it?” he asks. With such a competitive market, Huseby thinks costs for consumers will actually go down. “I think they’re not going to get the money from us, they’re going to have to get it from advertising. Advertising revenue will absolutely help pay for the bandwidth.” (The problem is that mobile advertising revenue is still relatively small and doesn’t usually go to carriers.)

—Holding onto consumers. “If they’re going to pay for it with advertising, they need to get a much firmer grip on their customers,” Huseby says. He sees this as a crucial issue for the coming decade. “The next viral social network has to work hard to make [ad revenues] accrue to them. Carriers have to be very conscious of the demographics of their customers. They have to get their customers anchored in.”

After his talk, I had a chance to ask Huseby about some other areas of interest, like mobile search. He says he’s generally staying out of that space, but is looking at location-based services from the perspective of retail stores and local advertising.

We’ll have more from the conference soon, so watch this space.

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Robots have already found limited work in healthcare by assisting surgeons with operations and physical therapists with rehabilitating patients, among other jobs. So why can’t robots keep an eye on seniors and give them their medications?

Bedford, MA-based iRobot (NASDAQ:IRBT) made headlines last month with the announcement of its recently created healthcare division, which is being headed by veteran software entrepreneur Tod Loofbourrow. The company’s ambitious plan is to develop a robot to help seniors live independently in their homes—something that no other company has accomplished. To learn more, I headed over to the firm’s headquarters last week.

The 7-year-old in me hoped to show up at iRobot and find the “medical droid” from Star Wars. But I knew not to expect to see such a humanoid robot, so I wasn’t disappointed when Loofbourrow told me that there were no healthcare robots to show me. Yet at one point during our interview, he flipped open his laptop and showed me a conceptual video of one of the company’s robots rolling over to an elderly person’s bedside and placing a bottle of pills on a side table. He said the video was intended to illustrate the company’s long-term vision for a healthcare robot, but the robot depicted was not a prototype of what the firm plans to market initially.

The senior citizen in the video, however, represented the first demographic iRobot aims to serve with a healthcare robot. There could be tremendous value in a robot that could help seniors live at home and avoid nursing homes, Loofbourrow explained, noting that the average nursing home in Massachusetts costs about $10,000 a month. Supporting patient care in the home may also help seniors avoid costly hospitalizations, which are a major factor in the whopping $2.4 trillion annual healthcare bill in the U.S. But the U.S. healthcare system hasn’t fully embraced using telemedicine—let alone robots—to enable patients to receive care in their homes.

Nevertheless, the leadership of iRobot decided that the time is right to launch a healthcare division, Loofbourrow said. The company has been interested in how its robots could be used to help patients for more than a decade. Indeed, company chairman and CEO Colin Angle told me back in 2006 that a robot for home healthcare was about three years from the market. And two years ago I spotted a concept robot the company developed called “CiCi” at a medical technology conference; an MIT robotics engineer told me for this Mass High Tech story that the stationary robot had two-way audio and remote-monitoring capabilities. Healthcare could eventually become a major business for iRobot, which already has succeeded in introducing robots like the Roomba for the household market and the PackBot for the military market.

“The company sees an opportunity to really transform a market,” Loofbourrow said. “So I’m here to build a very big business and a third leg of the stool for iRobot.”

Loofbourrow’s fascination with robotics dates back at least as far as his teenage years. As the Boston Globe’s Scott Kirsner reported in his blog post last month, Loofbourrow was16 years old when he wrote a book called “How to Build a Computer-Controlled Robot” in the late-1970s. He explained that when he was a child, his father was an engineer at Bell Labs and their basement was filled with circuit boards and other parts for building robots. The robot he built around a single-board microprocessor featured voice recognition and ultrasonic navigation, he said.

The Harvard University graduate was most recently founder and CEO of Waltham, MA-based Authoria, a provider of talent management software that Loofbourrow grew into a $40 million annual business with more than 300 employees in the U.S., Europe, and India. He sold the company in 2008 to White Plains, NY-based Bedford Funding for …Next Page »

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