CG Therapeutics, Immune-Booster For Cancer, Recruits Dendreon Vets, New CEO

3/10/09Follow @xconomy

Flameouts are the norm for any company that dares to try to stimulate the body’s immune system to fight cancer cells. Cell Genesys, Genitope, Favrille, and Antigenics have been added to the long list of companies that have stumbled in this promising field that hasn’t yet produced a single FDA-approved therapy. One of the sector leaders, Seattle-based Dendreon (NASDAQ: DNDN), is awaiting critical results next month which could validate, or crush, its immune-booster for prostate cancer, Provenge.

Given the hundreds of millions of investor dollars that have been sunk already into these active immunotherapies—sometimes called “cancer vaccines”—why would anybody listen to another startup pitch? Maybe I’m a glutton for punishment, but since Seattle-based CG Therapeutics has recruited two Dendreon veterans to its board, attracted capital from prominent Seattle investor Robert Arnold, and hired a new CEO, I figured it couldn’t hurt to hear the story.

CG Therapeutics’ new CEO is Denise Harrison, who got her biotech experience as chief financial officer of Seattle-based Illumigen Biosciences. That company was sold in December 2007 to Lexington, MA-based Cubist Pharmaceuticals. She’s getting some advice in this first go-round as a CEO from two new board members: Reiner Laus, the CEO of BN Immunotherapeudics and former vice president of R&D at Dendreon, and Julie Eastland, the chief financial officer of Seattle-based VLST and a former vice president of strategic planning at Dendreon.

CG has fixed its sights on a hormone that inspired the company name—hCG. Scientists have known for decades that this hormone plays a key role in early development, when it protects the fetus from being attacked by the immune system (it’s the thing that confirms when a woman is pregnant, turning the test kit blue). Researchers later came to understand this hormone can appear later in life, playing a more nefarious role. It offers that same brand of protection to tumor cells, cloaking them from an immune system that might otherwise kill them like an invading virus.

The company’s scientific team, led by Immunex veteran Tom Hopp, say they have designed a method to lift that protective veil from tumors. Their drug CG-201 aims to do this by taking some synthetic peptides that train the immune system to recognize hallmark signatures of hCG, and fuses them to a diphtheria toxin like the one found in the common DPT childhood immunization. This is supposed to make the hormone look like a foreign invader the immune system should attack.

By knocking out hCG, the company scientists hope they can attack the tumor’s support network on multiple levels. Besides offering protection from the immune system, the hormone is also thought to play a role in cancer by nourishing tumors through helping grow new blood vessels, and by allowing tissues to break down near the tumor that allows it to spread through the body, Hopp says.

An earlier version of CG-201 showed some positive signs, but not enough to move ahead in development, and besides, that intellectual property now belongs to Portland, OR-based AVI Biopharma, Harrison says. So CG’s scientists cooked up a new version on their own, which they say has been shown to be 10 times more potent, and longer-lasting, than the earlier one in rabbit experiments. It’s now ready to go into clinical trials.

Except there’s one big catch. … Next Page »

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  • Lorraine Morgan

    I think this is wonderful news! Just a shame that Big Venture capitalists are frightened to invest! What can be done? As a Breast Cancer victim myself and other members of my family have had various types of Cancer…it gives me hope!

  • Richard Lentini

    In the mid-1970s I had a MS degree in medical physiology and was working on a Ph.D. in experimental pathology at the University of Florida medical school. I noticed medical literature showed that the most aggressive cancers (the most dedifferentiated and metastatic cancers) produced hCG (or perhaps hCG subunits). I was intrigued by this and wanted to study this phenomenon because hCG also seemed to protect the fetus by way of the trophoblast. Unfortunately, my major professor was not intrigued about this phenomenon and I was not able to complete my Ph.D. degree. I completed everything but a dissertation which would have been a study involving the immunosuppression effects of hCG in cancer.

    I now have small cell lung cancer yet cannot, under any circumstances, get anti-hCG to see if it would prolong my life. This is so frustrating because I was sure hCG was so important in cancer research.

    Richard S. Lentini
    ricklend@yahoo.com

  • http://www.cancerbacteria.com Ron Falcone

    the relationship between hCG and cancer has been well known for over twenty years; AVIbiopharma was the first to launch an anti-hCG trial and showed statistically significant results but that effort was scrapped while Eli’s drug Gemzar—incidentally, one of the co-drugs tested with AVI’s hcg formulation and which didn’t show more superior levels of efficacy— remains the ‘approved’ drug but with a higher toxicity profile and far greater expense profile. Does economics have anything to do with it?