Supersized Ambitions: VentiRx Aims to be Extra-Large Player in Cancer, Allergy Medicines

1/7/09Follow @xconomy

They love their coffee at VentiRx. They love it so much that they named their San Diego- and Seattle-based biotech company after the extra-large size of beverage containers that Starbucks shrewdly branded for its menu. The name also happens to symbolize VentiRx’s supersize ambitions for creating new drugs against cancer and inflammatory diseases.

Naturally, I had to catch up with the company’s scientific co-founder, Rob Hershberg, at a Starbucks in downtown Seattle and order a venti coffee myself. (I think he actually got a grande something, but I didn’t take notes on what it was). Hershberg, a molecular biologist and former Harvard Medical School professor, got his biotech experience as chief medical officer at Seattle-based Dendreon (NASDAQ: DNDN), and a key scientific role before that at Corixa. His co-founder on the business side, Michael Kamdar, made his mark negotiating deals at San Diego-based Anadys Pharmaceuticals (NASDAQ: ANDS).

The VentiRx duo has raised $29 million in venture capital from Arch Venture Partners, Frazier Healthcare Ventures, and Domain Associates. The money is going toward building a portfolio of conventional small-molecule drugs designed to work in new ways against cancer and inflammatory diseases. Specifically, the company’s lead drug candidate is supposed to amplify the body’s front-line defense against disease —the innate immune system—to kill cancer cells in combination with other treatments. The company’s second candidate builds on the company’s immunology expertise to make a drug that creates a diversion of sorts that tamps down an overactive response that causes allergies. Something like 30 million people in the U.S. complain of allergies, so anything that works, and is convenient, is a venti-sized opportunity.

“It’s gonna be big,” Hershberg says, with a cheeky nod to the company name.

One thing that’s designed to stay small at VentiRx is the payroll. The company has a total of just 12 employees, with the R&D operations led by Hershberg in Seattle, and the business and finance side in San Diego run by Kamdar. The two of them run the company like co-CEOs, Hershberg says, and have made a pact to talk every day and see each other in person at least once a week, he says.

The game plan is to keep the company lean and hire outside contractors to do much of the work, or operate as a “virtual company” in the language of the VCs, Hershberg says.

VentiRx got its start in 2005 and 2006 with $2 million in seed capital from Arch and Frazier, and some key guidance from Arch managing director Steve Gillis, a mentor of Hershberg’s when they were both at Corixa. They had a shared enthusiasm for emerging biology around Toll-like receptors (TLR’s), key components of the innate immune system that recognizes foreign invaders at their point of entry under the skin, in the mucus linings of the nose, and the lining of the gut, Hershberg says. (This is different from the adaptive immune system, which forms B cells and T cells that develop memory capability to protect against certain pathogens.)

Kamdar had experience cutting a huge deal for Anadys with Swiss pharma giant Novartis, worth as much as $550 million to the smaller company, to co-develop drugs that modify a target called TLR7. So he was seen as the right match on the business side for VentiRx, Hershberg says.

Once they got the seed capital, Hershberg and Kamdar looked around the pharmaceutical industry for diamonds in the rough—potential drugs that could be used against TLRs. One candidate they found appealing was made by chemists at Boulder, CO-based Array Biopharma to stimulate TLR8. This seemed like a good candidate because TLR8 is found in primates and humans, but not in mice, so this was likely to fly below the radar of a lot of researchers, Hershberg says. “A lot of people in immunology think that if you can’t do it in the mouse, it won’t work,” he explains.

Since this target is found on dendritic cells, which recruit immune system T cells to attack foreign invaders, this was seen as a good potential immune-boosting treatment for cancer. VentiRx licensed the drug and chemically transformed it from a small-molecule pill into a form that’s given via a weekly shot just under the skin, which was thought to be more effective. VentiRx cleared all the necessary re-formulation, and animal testing steps, including those in non-human primates, in less than 18 months. The company entered its first clinical trial last month with 20 patients at the Mayo Clinic Arizona and TGen Drug Development Services in Scottsdale, AZ. The drug, code-named VTX-2337, should produce its first set of results this year, Hershberg says.

The drug is made to circulate throughout the body, in low doses, because researchers want to make sure this stimulation doesn’t go too far and provoke an out-of-control whole-body allergic reaction. Essentially, a little bit of immune stimulation can be good, but too much could be dangerous. The most vivid example of this, and something global regulators remember, was a 2006 incident in which six healthy volunteers fell critically ill after taking an experimental antibody drug from German drugmaker TeGenero during a clinical trial in the United Kingdom.

“We made sure we were confident about the pharmacology and toxicology before we moved,” into clinical trials, Hershberg says, of the response to the TeGenero incident.

While that drug marches through the clinic, VentiRx is teeing up a second candidate for allergic rhinitis (stuffy nose.) This candidate is built on emerging evidence behind what’s called the “hygiene hypothesis” that says that allergies, or an over-sensitive immune system, are more common in First World countries like the U.S., but not so much in developing countries, where people’s immune systems are thought to adjust after they have been exposed regularly to microbial invaders.

By giving tiny doses of a TLR stimulator, in a once-weekly nasal spray, VentiRx thinks it might be able to mimic this immune reaction as a sort of diversionary tactic, which could dampen an over-active allergic response or maybe prevent it in the first place, Hershberg says. That drug is in the final stages of paperwork needed to enter clinical trials, and VentiRx hopes to begin that clinical trial in Europe in early 2009, Hershberg says.

As a private company, Hershberg won’t say what kind of financial resources it has to move these programs ahead, but he gave the impression that staying small has enabled it to conserve a lot of its cash. The company already has had some talks with potential partners, although he didn’t promise a deal anytime soon. So at least for now, Hershberg says, VentiRx plans to stay small while building a portfolio it hopes will be big.

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  • http://www.BiotechStockResearch.com David Miller

    Rob is one of the smartest biotech guys I know. VentiRx’s approach is a potentially revolutionary one. There is great power and opportunity in the innate immune system and the first company to harness that will be a very valuable one.