The Pros (and Not Many Cons) of Merck’s HPV Vaccine, According to UW’s Laura Koutsky

12/3/08Follow @xconomy

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was postponed at the end of October while the alliance figures out how to best allocate its money during the financial crisis, Tsu said.

Koutsky, who said she doesn’t own Merck stock or receive any payment from the company, said she’s hopeful that competition will bring down the price over time. GlaxoSmithKline’s vaccine Cervarix, which isn’t yet approved by the FDA, could offer a competitive threat that brings down the price over time, she says.

Since this talk is called Science on Tap, I should probably relate some of the science Koutsky covered. One reason HPV is such a good candidate for a vaccine is that its viral genome is stable, and not constantly mutating and creating a moving target for a vaccine, like HIV does. The outer shell of the virus is also highly immunogenic, which means that it provokes antibodies to fight it right away. The vaccine is also made by using yeast cells as miniature drug factories, which means that Merck pays a royalty to the Washington Research Foundation on the latter’s intellectual property for making proteins in yeast. That could be a boon to the UW for years to come, since that vital intellectual property doesn’t expire until 2014.

Even though she didn’t point to many cons to the vaccine in her prepared talk, Koutsky had a pretty balanced view of the pharmaceutical industry when pressed. She encouraged some of the young scientists in the audience to consider jobs at Merck, but to go in with their eyes wide open. “The scientists at Merck are top-flight,” she said. “I’d encourage you to look at it, because they have tremendous resources and a tremendous agenda to get something done. Sometimes in the public sector we wonder what the heck we’re working on, and what we’re trying to accomplish.”

But all that focused energy sometimes means that science takes a backseat. Afterward, Koutsky related a story that Tsu told her, that HPV vaccine is being marketed to older women in Argentina who have the money to pay for it, even though it’s most effective for young women before they become sexually active. “Once you have a product in the pharmaceutical industry, then marketing becomes involved,” Koutsky said.

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  • Krassen Dimitrov

    This is a disappointing article in that it mentions Merck several times, yet fails to acknowledge the inventor of the vaccine and the company that developed it.

    Readers may be interested to know that Gardasil was invented by Prof. Ian Frazer at the University of Queensland and was developed by an Australian company (CSL).

    To recognize this great achievement, Prof. Frazer was named Australian of the Year in 2006. While it may be suitable for some young scientists to consider careers at Merck, others may want to become the next Ian Frazers, and work in a University.

    And now, that the repugnant, Republican-led War on Science is about to be ended by President Obama, maybe American scientists will soon be able to get the same recognition that scientists all over the world get.

    Disclaimer: I work at the University of Queensland

  • HPV Vaccine book

    FYI- There is a new book on the HPV vaccine:The HPV Vaccine Controversy- Sex, Cancer,God and Politics which gives an unbiased opinion of the vaccine. It is available on amazon.com and is written for the public.

  • Adam

    I have been reading alot latly on Vaccines. Most sites that say Vaccines are good and should be used never say anythign about they make up of the finished product and how we are bypassing out own bodies natural immune system to deliver a Vaccine that is not 100% affective and possibly has not even had enough testing. Look at the history of Vaccinations since the early 1400′s. even tho these vaccinations killed people the government allowed these Vaccination to be used over and over and over again. even after they abloish it. years later they appove to start testing and using them again even tho they kill people. look at the 1918 influenza outbreak. it was caused by our own government. heck even look at the gulf war syndrom. our government does it again. Injecting out own troops with anthrax???? and not testing it fully. everything i have read has been jaw dropping but yet everytime i see a site that says yes Vaccines should be taken yearly are beyond me. even the flu vaccine. why would people want to inject stuff in there body like aborted fetus cells, murcury/Trimerisol, and formaldehyde “just to name a few” witch is a known carsenogen. Murcury/Trimerisol is a known contributer to the cause of autism with was never heard of until we started injection kids with it. hell cancer was unheard of until we started injecting with vaccines. I wish my parents would have been informed of this when i was young. I will never give my family a shot that can harm them. As for Vaccines the governmant makes so much money in it. thats why someone with aids can go to another country and be cured of it. but that same natural cure is illigal in the USA. why??? cuz it takes away from the governments pocket book. its sad. something that only cost 36 bucks for a 20 oz cure that is natural and does not need to be taken by injection but oraly drank and uses your own bodies immune system natural to CURE aids. something that also did not come around until we started injecting vaccines. look at SV40 in the 50′s and 60′s they said it was safe but yet it causes cancer. i tihnk the government does not have the public in there interestes and our government should be abolished by the people and new government instatuted. unfortunantly the world is lazy and blind to these things. feel free to write back i would likie to bsee your point of view along with any cretible info you have. ya i may be a lower middle class highschool drop out but with all the new laws the government can write they are terrorist by there own laws but other laws say they can do it because they are the government. they can legaly inject us without our verbal consent because our consent is automaticaly assumed unless we otherwise say so. scanners in airports are known to kill cells but yet the government says we have to go through them. why does our government want to kill us?

  • S. Tolan

    the vaccine was not just developed by Queensland:
    “developed, in parallel, by researchers at Georgetown University Medical Center, the University of Rochester, the University of Queensland in Australia, and the U.S. National Cancer Institute.”

    McNeil C (April 2006). [jnci.oxfordjournals.org/cgi/content/full/98/7/433 "Who invented the VLP cervical cancer vaccines?"]. J. Natl. Cancer Inst. 98 (7): 433. doi:10.1093/jnci/djj144. PMID 16595773. jnci.oxfordjournals.org/cgi/content/full/98/7/433. Retrieved 2009-11-11.

  • Tom

    The vaccine is not 100% effective at preventing HPV, as indicated by the Koutsky clinical trial data’s non-zero incidence rate of HPV infection. It may be 100% effective at building immunity to the disease, but I found that statement misleading.