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financial deal ever. He was previously the founder and CEO of Mpex Pharmaceuticals, acquired by Aptalis in 2011, and Medlyte Therapeutics (now Lpath Therapeutics).
Terms of the deal call for Sunovion to make an upfront payment of $100 million, which means the VCs would realize an immediate return that is at least twice their investment. If development of Elevation’s drug-and-device combo successfully continues, additional milestone payments would return almost 10 times the venture investment.
Brent Ahrens, a general partner in Canaan Partners Menlo Park, CA, office, led the Series A round of $31.6 million, which closed with a first tranche of $14.6 million in January 2010. “Think of the value the team created,” Ahrens told me by phone this afternoon. “It was pretty strongly up and to the right.” Including all expected returns, Ahrens said, “From the time we invested until today, the value creation is on the order of a half-million dollars a day. That’s pretty remarkable.”
Other investors include Novo Ventures, TPG Biotech, Care Capital, and Mesa Verde Venture Partners.
COPD, also known as emphysema and chronic bronchitis, is the third leading cause of death in the U.S., according to the Centers for Disease Control. About 12 million Americans are estimated to have COPD, and another 12 million have not been diagnosed, according to the National Institutes of Health. Elevation’s drug-and-device combo targets a segment of the market that consists of more than 1 million Americans with severe or very severe COPD, and who are typically very young or very old patients, Gerhart says.
In a joint statement, Elevation’s Gerhart says, “Nebulized medicine is an important treatment option for older and sicker patients—the fastest growing segment within COPD.” Hiroshi Nomura, Sunovion’s vice chairman, said the acquisition will strengthen and diversify the company’s portfolio of respiratory drugs.
The boards of both companies have approved the deal, which is subject to customary closing conditions.
In addition to the upfront payment, Sunovion agreed to make milestone payments of up to $90 million for EP-101. If EP-101 wins regulatory approval, additional commercial milestone payments could total as much as $210 million. Another $30 million is contingent on the successful development of other drug programs.