San Diego’s ReVision Therapeutics, Founded in April, Takes on Development of Drug Candidate for Age-Related Blindness

8/31/10Follow @bvbigelow

A San Diego biopharmaceutical startup, formed just five months ago to resume development of a compound for treating age-related macular degeneration, has reported encouraging results from a two-year, mid-stage clinical trial of the compound, known as fenretinide.

The findings were released in Florida yesterday at the annual meeting of the American Society of Retinal Specialists and in San Diego today by ReVision Therapeutics, the biotech started in April with venture funding led by Avalon Ventures, which was joined by Advent Healthcare, Aisling Capital, Atlas Capital, Investor Growth Capital, and Novaquest. (The biopharmaceutical startup is not to be confused with Rhevision Technology, another San Diego startup with a similar name that is developing miniature tunable camera lenses for mobile phone handsets.)

Avalon’s Jay Lichter declined to say this afternoon how much capital ReVision has raised to acquire fenretinide and to restart development of the drug in San Diego. He would only say that ReVision now has ample resources to analyze the data accumulated on fenretinide so far—and to continue development of the drug as a treatment for macular degeneration, a chronic deterioration of the central portion of the retina. The age-related condition is a leading cause of blindness in people 60 and older, and affects some 1.8 million Americans, according to the National Eye Institute.

The deal to acquire the compound and start ReVision means fenretinide has come full circle. It was initially under development as a potential treatment for macular degeneration by Sytera, a San Diego-based company founded in 2004. But development of the drug moved to Tampa, FL-based Sirion Therapeutics, an ophthalmic-focused biopharmaceutical that acquired fenretinide through its 2006 merger with Sytera. Sirion conducted the mid-stage clinical trials at a number of sites throughout Florida, and Lichter says the last patient left the trial in April.

Sytera was founded to develop fenretinide by Kevin Kinsella, the founder of San Diego-based Avalon Ventures, and Ken Widder (now with Latterell Venture Partners of San Francisco), with help from Avalon’s Lichter, Nathan Mata, and Gabriel Travis, a professor of biochemistry at UCLA. Kinsella, who was on Sirion’s board, and Lichter led … Next Page »

Bruce V. Bigelow is the editor of Xconomy San Diego. You can e-mail him at bbigelow@xconomy.com or call (619) 669-8788 Follow @bvbigelow

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