Comments on: Arena Obesity Drug Helps Patients Shed a Few Pounds, Lower Risk of Heart Disease http://www.xconomy.com/san-diego/2009/06/06/arena-obesity-drug-helps-patients-shed-a-few-pounds-lower-risk-of-heart-disease/ Business + Technology in the Exponential Economy Sun, 22 Nov 2009 19:43:29 -0600 http://wordpress.org/?v=2.8.6 hourly 1 By: What Is Bodyfat? | Amazing Weight Loss Program http://www.xconomy.com/san-diego/2009/06/06/arena-obesity-drug-helps-patients-shed-a-few-pounds-lower-risk-of-heart-disease/comment-page-1/#comment-64199 What Is Bodyfat? | Amazing Weight Loss Program Mon, 08 Jun 2009 04:07:12 +0000 http://www.xconomy.com/?p=28312#comment-64199 [...] Arena Obesity Drug Helps Patients Shed a Few Pounds, Lower Risk of Heart Disease (xconomy.com) [...] [...] Arena Obesity Drug Helps Patients Shed a Few Pounds, Lower Risk of Heart Disease (xconomy.com) [...]

]]> By: Lefty http://www.xconomy.com/san-diego/2009/06/06/arena-obesity-drug-helps-patients-shed-a-few-pounds-lower-risk-of-heart-disease/comment-page-1/#comment-64041 Lefty Sat, 06 Jun 2009 16:28:37 +0000 http://www.xconomy.com/?p=28312#comment-64041 "A hit drug in this disease would need to help people shed between 10 percent and 15 percent more of their body weight than a placebo" Either you've misinterpreted him, or Pi-Sunyer is an absolute moron. This sort of efficacy is IMPOSSIBLE (except in a small sub-population of drug responders, which was in fact observed in the lorcaserin data). It's not that different from claiming that a cancer drug will only be successful if it induces 10yr remission in >90% of late-stage patients: absolutely unrealistic. Did you know that none of the available weight loss drugs (current or past) have met the 5% adjusted placebo criteria? Did you know that rimonabant, Wall Street's 'savior' of obesity, also failed to meet this criteria? I'm just so tired of the incompetence that passes for scientific and medical interpretation in the financial world...and, if Pi-Sunyer actually said that, apparently a fringe portion of the medical world as well. Oh, and nice professional headline: "helps patients shed a few pounds". Laughably unobjective. “A hit drug in this disease would need to help people shed between 10 percent and 15 percent more of their body weight than a placebo”

Either you’ve misinterpreted him, or Pi-Sunyer is an absolute moron. This sort of efficacy is IMPOSSIBLE (except in a small sub-population of drug responders, which was in fact observed in the lorcaserin data). It’s not that different from claiming that a cancer drug will only be successful if it induces 10yr remission in >90% of late-stage patients: absolutely unrealistic.

Did you know that none of the available weight loss drugs (current or past) have met the 5% adjusted placebo criteria? Did you know that rimonabant, Wall Street’s ’savior’ of obesity, also failed to meet this criteria?

I’m just so tired of the incompetence that passes for scientific and medical interpretation in the financial world…and, if Pi-Sunyer actually said that, apparently a fringe portion of the medical world as well.

Oh, and nice professional headline: “helps patients shed a few pounds”. Laughably unobjective.

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