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Fate Therapeutics Starts First Clinical Trial of Drug to Boost Stem Cell Transplants

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Arch Venture Partners to form Fate, which is focused on the development of drugs intended to activate adult stem cells to treat diseases.

Dana-Farber, one of the world’s leading centers for adult stem cell transplants, is expected to be the clinical trial site for all 12 patients who will enroll in the Phase Ib study. The trial enrolled its first patient last week and is expected to end next year. Each patient will receive two different supplies of stem cells from different donors, and one of the two supplies will be treated with Fate’s drug for an hour before it is infused into patients. The primary purpose of the study is to test the safety of the drug. Yet by designing the trial to have a control group, Fate also hopes to get a preliminary sense of whether the drug is working, specifically, whether the stem cells treated with the drug are able to better multiply and find their way into bone marrow more quickly than the untreated stem cells. Fate hopes to show in future trials that the the drug can speed up the time needed for the stem cell transplants to restore immune function and blood production.

Cord blood—drawn from umbilical cords and placentas after babies are born—is a good source of stem cells for transplants because it requires less of a match from donor to patient than sources such as donated bone marrow or blood that circulates through the rest of the body, according to Fate. Because of this, patients often don’t need to wait as long for stem cell transplants from cord blood supplies as they do for transplants from the other two sources. Fate isn’t alone in developing ways to improve cord blood transplants; other companies—including Durham, NC-based Aldagen, Gamida Cell, of Jerusalem, Israel—are developing methods to increase stem cell numbers in cord blood supplies.

Despite its name, Fate wasn’t leaving anything to chance when selecting Dana-Farber to conduct the trial. “Transplantation itself is a very intense procedure, so you want to work with the best to make sure that’s not a variable in your study,” Multani said.

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  • Heidi

    This is really great news. Our stem cell research is way behind other countries.
    In addition to this, stem cell research for Emphysema and other serious lung problems needs to get underfoot also. Thousands of people are dying because stem cell research was not allowed by our previous Administration.