Anadys Hepatitis C Drug Shows Potent Effect in Small Study
San Diego-based Anadys Pharmaceuticals generated a ton of buzz almost four months ago when it offered an early peek at data suggesting its hepatitis C drug might be working, and now a presentation of the full data appears to reinforce the first impression.
Anadys’ lead drug candidate, ANA598, was able to wipe out more than 99 percent of the hepatitis C virus at all three doses tested in a trial of 35 patients, according to data presented today at the European Association for the Study of the Liver meeting in Copenhagen, Denmark. No patients had any serious side effects, and none showed signs of developing resistance to the drug or having their virus bounce back while taking the pill twice-daily over three days.
“The potent antiviral activity demonstrated at all three doses in this study is very encouraging for the prospects of ANA598 when used in combination with other HCV agents,” said Anadys CEO Steve Worland, in a statement. Hepatitis C is an infection of the liver caused by virus.
Anadys has been on a roll since January, when the company offered an initial peek at data that said ANA598 was working in the first cohort of patients who got the lowest dose, 200 milligrams twice a day. Investors are jazzed about this research, causing Anadys stock (NASDAQ: ANDS) to more than double since then. That’s because more than 170 million people worldwide have hepatitis C infections, and Anadys is part of a burgeoning wave of innovation in the biotech industry to treat this liver-damaging disease. More than 40 different drugs are in development, and they are likely to be used in HIV-style cocktail treatments to prevent the virus from developing resistance, Worland told me last month.
Cambridge, MA-based Vertex Pharmaceuticals is leading the way with its protease inhibitor, while other companies are developing nucleoside polymerase inhibitors. Non-nucleoside polymerase inhibitors like ANA598 ought to attack the virus from different angles and keep it in check, Worland says.
Investors are hoping Anadys can parlay this new clinical data … Next Page »