RXi Sells Stock and Warrants, Cardiorobotics Raises $6.6M, ImmunoGen Dishes On New Drugs, & More Boston-Area Life Sciences News
This week we’ve seen news of financings for device makers and drug developers, as well as reports from clinical trials from New England area life sciences firms and their rivals.
—Daniel Junius, CEO of Waltham, MA-headquartered ImmunoGen, talked to Ryan about the antibody-based drugs the company is developing that aren’t generating as much noise as the ImmunoGen technology used by Genentech to create a more powerful breast cancer drug. ImmunoGen is working on two new treatments that each link an antibody with anti-cancer toxins, for treating non-Hodgkin’s lymphomas, and breast, lung, and ovarian tumors.
—The FDA did not grant approval to a drug produced by Israel-based Protalix Biotherapeutics that rivals Cambridge, MA-based Genzyme’s treatment for Gaucher’s disease. Regulators raised questions about clinical matters, chemistry, manufacturing, and controls related to taliglucerase alfa, developed by Protalix in partnership with Pfizer.
—Speaking of rivals to Boston biotechs, Germany-based Merck KGaA failed to garner FDA approval for its experimental MS pill cladribine because the regulators wanted more safety data on the drug. The news comes as Weston, MA-based Biogen Idec (NASDAQ: BIIB) is testing its own oral MS treatment, dimethyl fumarate (BG-12).
—Marlborough, MA-based med device developer CardioFocus raised $30.6 million in financing from new investors First Alliance & Capital Invest, Fletcher Spaght Ventures, and Manatuck Hill Parnters, as well as all previous investors. The firm is developing a system for laser ablation procedures used in treating an irregular heart rhythm known as atrial fibrillation.
—Cambridge drug developer NeuroPhage Pharmaceuticals said it raised $12.4 million in a Series B financing led by Mérieux Développement, the healthcare investment arm of French firm Institut Mérieux, with backing from Irish biopharma company Shire (NASDAQ: SHPGY). The deal represents the firm’s first institutional financing; the cash will go toward funding NeuroPhage’s clinical trials of its lead drug candidate NPT001, a treatment for Alzheimer’s disease.