Comments on: Genzyme, Isis Cholesterol Drug Reaches Goal in Pivotal Study, Paving the Way to FDA http://www.xconomy.com/boston/2009/05/20/genzyme-isis-cholesterol-drug-reaches-goal-in-pivotal-study-paving-the-way-to-fda/ Business + Technology in the Exponential Economy Sun, 22 Nov 2009 23:12:44 -0600 http://wordpress.org/?v=2.8.6 hourly 1 By: iguanabio http://www.xconomy.com/boston/2009/05/20/genzyme-isis-cholesterol-drug-reaches-goal-in-pivotal-study-paving-the-way-to-fda/comment-page-1/#comment-59300 iguanabio Wed, 20 May 2009 21:39:14 +0000 http://www.xconomy.com/?p=25741#comment-59300 pts with HFH can be controlled on apheresis which runs $30-40k/year...a lot cheaper than I'm sure this will be. Plus, the LDL drop is insignificant in patients with 1000+ LDLs. The big prob though is liver tox, and one patient in such a small group is concerning. If the strategy is to go for a larger, less severe population then safety will be key. will be difficult iguanabio.com pts with HFH can be controlled on apheresis which runs $30-40k/year…a lot cheaper than I’m sure this will be. Plus, the LDL drop is insignificant in patients with 1000+ LDLs. The big prob though is liver tox, and one patient in such a small group is concerning. If the strategy is to go for a larger, less severe population then safety will be key.

will be difficult

iguanabio.com

]]> By: Mipomersen - It Still Works « Pharma Marketer http://www.xconomy.com/boston/2009/05/20/genzyme-isis-cholesterol-drug-reaches-goal-in-pivotal-study-paving-the-way-to-fda/comment-page-1/#comment-59280 Mipomersen - It Still Works « Pharma Marketer Wed, 20 May 2009 19:07:57 +0000 http://www.xconomy.com/?p=25741#comment-59280 [...] several other cardiovascular risk factors at the same time. Isis and their partner Genzyme have just announced that a trial of the drug in patients with homozygous familial hypercholesterolemia showed [...] [...] several other cardiovascular risk factors at the same time. Isis and their partner Genzyme have just announced that a trial of the drug in patients with homozygous familial hypercholesterolemia showed [...]

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