Comments on: Follica Gets New CEO, Gears Up for More (Hair and Business) Growth http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/ Business + Technology in the Exponential Economy Sun, 22 Nov 2009 23:52:13 -0600 http://wordpress.org/?v=2.8.6 hourly 1 By: jordan http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93635 jordan Sun, 22 Nov 2009 18:21:13 +0000 http://www.xconomy.com/?p=24501#comment-93635 does anyone know when we will be looking to get the results of the asain trails? does anyone know when we will be looking to get the results of the asain trails?

]]> By: James http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93434 James Fri, 20 Nov 2009 00:00:52 +0000 http://www.xconomy.com/?p=24501#comment-93434 Oh and Aderans published this in August http://hmg.oxfordjournals.org/cgi/content/abstract/ddp509 More on the role of good ole WNT and Adernans have been attending this a few days ago: https://www.spgeventformer.com/lifetechnologies/2009/ctis/attendee/index.cfm Interesting conference could read into why they attended and for what reasons? Oh and Aderans published this in August

http://hmg.oxfordjournals.org/cgi/content/abstract/ddp509

More on the role of good ole WNT

and Adernans have been attending this a few days ago:

https://www.spgeventformer.com/lifetechnologies/2009/ctis/attendee/index.cfm

Interesting conference could read into why they attended and for what reasons?

]]> By: James http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93432 James Thu, 19 Nov 2009 23:49:08 +0000 http://www.xconomy.com/?p=24501#comment-93432 Oh and for those of you aware of the Sonic The Hedge hog gene, heres some research you may or may not have seen: http://www.ncbi.nlm.nih.gov/pubmed/18987668 J Oh and for those of you aware of the Sonic The Hedge hog gene, heres some research you may or may not have seen:

http://www.ncbi.nlm.nih.gov/pubmed/18987668

J

]]> By: James http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93431 James Thu, 19 Nov 2009 23:42:25 +0000 http://www.xconomy.com/?p=24501#comment-93431 This might be nothing but at least its something when doing my normal scan I came across this.. http://www.linkedin.com/pub/gustavo-galdo/6/722/48 The interesting bit is that this person has just finished working for Aderans Research Group. "Quality Control Technician (Contract) Aderans Research Institute (Biotechnology industry) April 2009 — November 2009 (8 months) • Perform environmental monitoring of Clean Room and BSC • Conduct Endotoxin Testing, Rapid Mycoplasma testing and Label Inspections • Involved in sterility testing of human cell culture media and phase II cellular based product." This time coincides perfectly with phase II trials. Therefore this raises the question have the trials now finished? This might be nothing but at least its something

when doing my normal scan I came across this..

http://www.linkedin.com/pub/gustavo-galdo/6/722/48

The interesting bit is that this person has just finished working for Aderans Research Group.

“Quality Control Technician (Contract)
Aderans Research Institute
(Biotechnology industry)
April 2009 — November 2009 (8 months)
• Perform environmental monitoring of Clean Room and BSC
• Conduct Endotoxin Testing, Rapid Mycoplasma testing and Label Inspections
• Involved in sterility testing of human cell culture media and phase II cellular based product.”

This time coincides perfectly with phase II trials. Therefore this raises the question have the trials now finished?

]]> By: Dai http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93409 Dai Thu, 19 Nov 2009 18:55:59 +0000 http://www.xconomy.com/?p=24501#comment-93409 I really like the way Histogen is keeping everyone informed and uptodate. Wish Follica would do the same; the TOTAL silence on their part is puzzling. I really like the way Histogen is keeping everyone informed and uptodate. Wish Follica would do the same; the TOTAL silence on their part is puzzling.

]]> By: Maverick http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93376 Maverick Thu, 19 Nov 2009 09:24:00 +0000 http://www.xconomy.com/?p=24501#comment-93376 ZZ it is common sense that you wrote but if you listen to this interview from Gail Naughton(especially the second video) she said that we can expect a growth of TERMINAL hairs, she also said we might need some maintenance but if we see the recession but some of the new hairs do not fall out I believe that is a success for itself. At least I hope that this will kick Aderans and Follica in the ass to start working serious now. ZZ it is common sense that you wrote but if you listen to this interview from Gail Naughton(especially the second video) she said that we can expect a growth of TERMINAL hairs, she also said we might need some maintenance but if we see the recession but some of the new hairs do not fall out I believe that is a success for itself. At least I hope that this will kick Aderans and Follica in the ass to start working serious now.

]]> By: James http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93334 James Thu, 19 Nov 2009 00:27:08 +0000 http://www.xconomy.com/?p=24501#comment-93334 Thank you Seaborn! for bringing that to our attention... Shes certainly not afraid of putting her money were her mouth is! Only time will tell! Thank you Seaborn! for bringing that to our attention…

Shes certainly not afraid of putting her money were her mouth is!

Only time will tell!

]]> By: Seaborn http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93322 Seaborn Wed, 18 Nov 2009 21:02:42 +0000 http://www.xconomy.com/?p=24501#comment-93322 "Histogen’s HSC - Highly Anticipated Hair loss Treatment Due to Hit “Shelves” As Soon As 2013" Some interesting video interviews with Dr. Gail Naughton. http://www.thebaldtruth.com/articles/histogen%E2%80%99s-hsc-highly-anticipated-hair-loss-treatment-due-to-hit-%E2%80%9Cshelves%E2%80%9D-as-soon-as-2013/ “Histogen’s HSC – Highly Anticipated Hair loss Treatment Due to Hit “Shelves” As Soon As 2013″

Some interesting video interviews with Dr. Gail Naughton.

http://www.thebaldtruth.com/articles/histogen%E2%80%99s-hsc-highly-anticipated-hair-loss-treatment-due-to-hit-%E2%80%9Cshelves%E2%80%9D-as-soon-as-2013/

]]> By: jordan http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93316 jordan Wed, 18 Nov 2009 20:06:48 +0000 http://www.xconomy.com/?p=24501#comment-93316 the more afforable the treatment is the more will use it meaning they will have more profit. if its expensive only the rich use it and they wont make as much money the more afforable the treatment is the more will use it meaning they will have more profit. if its expensive only the rich use it and they wont make as much money

]]> By: ZZ http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93304 ZZ Wed, 18 Nov 2009 18:01:07 +0000 http://www.xconomy.com/?p=24501#comment-93304 Maverick, I don't really think it is by design but I believe you are correct that this will require maintenance in one form or another so in that respect it is similar to a propecia/rogaine regimen. At the low dose given in the safety trial, HSC grew and maintained hair for at least 3 to 4 months. Then by the fifth month there was apparently at least some regression in some but not all of the subjects. So this pretty much indicates that there will be regression in everyone at some point. However, some things to consider are: The benefits lasted 3-4 months from a very low dosage with no topical maintenance. At a higher dosage, I think it is reasonable to assume that the benefits (without topical maintenance) might last at least a little longer, say 6-7 months. So theoretically, it would not be unreasonable to assume that 2 injections per year could maintain the benefits. (Maybe $1,500 - $2,000 per year) In other words if 1 low dose is good for 3 months, I believe they are confident that 4 injections at a low dose should last at least 1 year. Hopefully, 2 stronger doses would last at least a year without need for topical maintenance. Or it could be that you get 2 injections the first year and then its just topical in subsequent years. And if the $1,500 projection for topical maintence is based on 52 application per year but they find in testing that you only need 1 per month, it is reasonable to assume that topical maintenance may cost much less than $1,500 per year. My very limited understanding was that the $5,000 injection amount, plus the $1,500 maintenance was an outside limit worst case scenario based on the limited understanding they have gained from the first trial. Also, remember that all subjects were on no other medication such as propecia. For individuals who are not opposed to propecia, it may greatly extend the benefits of HSC. The cost may also vary based on each person's individual response to HSC. Remember that some of the subjects in the low dose study had close to a 50% increase in hair count. I am not aware of such a huge differential in results in studies done with the existing options and I believe this might be a good clue that a higher dose may bring much greater and longer lasting results. Possibly individuals with severe forms of baldness might require more injections, more maintenance, etc. So maybe it would be more expensive for some than others. Maybe if you want thicker hair, you can opt for more applications. Of course, this is all just speculation and we don't even know if it will work at a consistent acceptable level or if it will end up being safe. I'm not trying to get everyone juiced up, I'm just passing along what little I think I have learned from the tidbits of information contained in the investor presentation and passing along my thought process. There is a long way to go. Maverick, I don’t really think it is by design but I believe you are correct that this will require maintenance in one form or another so in that respect it is similar to a propecia/rogaine regimen. At the low dose given in the safety trial, HSC grew and maintained hair for at least 3 to 4 months. Then by the fifth month there was apparently at least some regression in some but not all of the subjects. So this pretty much indicates that there will be regression in everyone at some point. However, some things to consider are: The benefits lasted 3-4 months from a very low dosage with no topical maintenance. At a higher dosage, I think it is reasonable to assume that the benefits (without topical maintenance) might last at least a little longer, say 6-7 months. So theoretically, it would not be unreasonable to assume that 2 injections per year could maintain the benefits. (Maybe $1,500 – $2,000 per year) In other words if 1 low dose is good for 3 months, I believe they are confident that 4 injections at a low dose should last at least 1 year. Hopefully, 2 stronger doses would last at least a year without need for topical maintenance. Or it could be that you get 2 injections the first year and then its just topical in subsequent years. And if the $1,500 projection for topical maintence is based on 52 application per year but they find in testing that you only need 1 per month, it is reasonable to assume that topical maintenance may cost much less than $1,500 per year. My very limited understanding was that the $5,000 injection amount, plus the $1,500 maintenance was an outside limit worst case scenario based on the limited understanding they have gained from the first trial. Also, remember that all subjects were on no other medication such as propecia. For individuals who are not opposed to propecia, it may greatly extend the benefits of HSC. The cost may also vary based on each person’s individual response to HSC. Remember that some of the subjects in the low dose study had close to a 50% increase in hair count. I am not aware of such a huge differential in results in studies done with the existing options and I believe this might be a good clue that a higher dose may bring much greater and longer lasting results. Possibly individuals with severe forms of baldness might require more injections, more maintenance, etc. So maybe it would be more expensive for some than others. Maybe if you want thicker hair, you can opt for more applications. Of course, this is all just speculation and we don’t even know if it will work at a consistent acceptable level or if it will end up being safe. I’m not trying to get everyone juiced up, I’m just passing along what little I think I have learned from the tidbits of information contained in the investor presentation and passing along my thought process. There is a long way to go.

]]> By: Maverick http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93263 Maverick Wed, 18 Nov 2009 09:48:41 +0000 http://www.xconomy.com/?p=24501#comment-93263 ZZ I thought so. I mean what is the profit for the company if they cure your problem once and never see you again? This is maybe harsh but this looks like another Propecia/Rogaine but more advanced and pricey. I sure hope that, that scenario will not be true. And for the sake of all of us I hope that someone else took that Sox21 gene research that those Japanese scientists gave their hands off. ZZ I thought so. I mean what is the profit for the company if they cure your problem once and never see you again? This is maybe harsh but this looks like another Propecia/Rogaine but more advanced and pricey. I sure hope that, that scenario will not be true. And for the sake of all of us I hope that someone else took that Sox21 gene research that those Japanese scientists gave their hands off.

]]> By: ZZ http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93208 ZZ Wed, 18 Nov 2009 02:10:06 +0000 http://www.xconomy.com/?p=24501#comment-93208 I hear you REV. But I think that is a worst case scenario. The trial they just completed was for safety so I believe they used a very minimal dosage. In the efficacy trials, I believe they will experiment with more potent amounts. Worst case you would need 4 injections per year plus topical but it could be just as likely that you could get 2 or 3 initial injections and then maintenance would be topical with no follow up injections unless maybe you wanted to try to grow additional hair. $6,500 per year would make for a fairly small market size. But this is all conjecture so let's wait and see what happens. They were supposed to have finalized their deal with the funding partner by Nov. 1 but I have not heard anything new. For now, I am just hoping they get the funding they need so that they keep keep this train rolling. I hear you REV. But I think that is a worst case scenario. The trial they just completed was for safety so I believe they used a very minimal dosage. In the efficacy trials, I believe they will experiment with more potent amounts. Worst case you would need 4 injections per year plus topical but it could be just as likely that you could get 2 or 3 initial injections and then maintenance would be topical with no follow up injections unless maybe you wanted to try to grow additional hair. $6,500 per year would make for a fairly small market size. But this is all conjecture so let’s wait and see what happens. They were supposed to have finalized their deal with the funding partner by Nov. 1 but I have not heard anything new. For now, I am just hoping they get the funding they need so that they keep keep this train rolling.

]]> By: rev http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93174 rev Tue, 17 Nov 2009 23:36:33 +0000 http://www.xconomy.com/?p=24501#comment-93174 I figured Histogen's treatment would be prone to DHT susceptibility, but I really don't like the sound of a $5000 treatment along with a $1500 annual regime. Let's hope further trials prove the initial treatment more potent because I'm awfully tired of pricey regimes. I figured Histogen’s treatment would be prone to DHT susceptibility, but I really don’t like the sound of a $5000 treatment along with a $1500 annual regime. Let’s hope further trials prove the initial treatment more potent because I’m awfully tired of pricey regimes.

]]> By: ZZ http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93164 ZZ Tue, 17 Nov 2009 23:21:17 +0000 http://www.xconomy.com/?p=24501#comment-93164 It didn't stop anything for me and I would almost say there was an increase in loss for several months after the treatment. But 2 points: I would only do pure PRP like Dr. Feller recommends if I were someone who was going to try it. Just an opinion but I think the protein plus feature may do more harm than good. I think it dilutes the potency b/c the injection is no longer just pure platelets but a mixture of platelets & protein. I think a protein matrix is only needed as a scaffold where you are injecting prp in a cavity such as a knee or a gaping hole in the skin. Obviously, that's not the case with the scalp. This was just my experience. I would try straight prp again if I didn't have to travel to do it. I don't think it will grow hair but it may help prevent further loss. Point 2 is that I took advil several times in the weeks after the prp treatment. If you get prp in a joint, the orthopod will tell you to only use tylenol, b/c naisids counteract the effects of the growth factors. Also, to address Mavericks comment on 11/1 above about dht resistence. That appears to be an issue with Histogen since they saw some regression at 5 months from the gains that were seen at 3 months. To address that, Histogen will experiment with anywhere from 2-4 injections per year possibly supplemented with topical applications no more than once weekly. The injections, depending on how many are required are projected to range between $1,500 & $5,000 per year and the topical would range up to $1,500 per year. But this is all early stage and certainly one of their goals will be to figure out the optimum treatment in their clinical trials. It didn’t stop anything for me and I would almost say there was an increase in loss for several months after the treatment. But 2 points: I would only do pure PRP like Dr. Feller recommends if I were someone who was going to try it. Just an opinion but I think the protein plus feature may do more harm than good. I think it dilutes the potency b/c the injection is no longer just pure platelets but a mixture of platelets & protein. I think a protein matrix is only needed as a scaffold where you are injecting prp in a cavity such as a knee or a gaping hole in the skin. Obviously, that’s not the case with the scalp. This was just my experience. I would try straight prp again if I didn’t have to travel to do it. I don’t think it will grow hair but it may help prevent further loss. Point 2 is that I took advil several times in the weeks after the prp treatment. If you get prp in a joint, the orthopod will tell you to only use tylenol, b/c naisids counteract the effects of the growth factors.

Also, to address Mavericks comment on 11/1 above about dht resistence. That appears to be an issue with Histogen since they saw some regression at 5 months from the gains that were seen at 3 months. To address that, Histogen will experiment with anywhere from 2-4 injections per year possibly supplemented with topical applications no more than once weekly. The injections, depending on how many are required are projected to range between $1,500 & $5,000 per year and the topical would range up to $1,500 per year. But this is all early stage and certainly one of their goals will be to figure out the optimum treatment in their clinical trials.

]]> By: CROMAN http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93138 CROMAN Tue, 17 Nov 2009 20:47:33 +0000 http://www.xconomy.com/?p=24501#comment-93138 FEW MONTHS ....FEW MONTHS...AND AGAIN AND AGAIN..I KNOW THIS STORY.SOME PEOPLE(NOT ME) are realy realy tired! FEW MONTHS ….FEW MONTHS…AND AGAIN AND AGAIN..I KNOW THIS STORY.SOME PEOPLE(NOT ME) are realy realy tired!

]]> By: Davey http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93118 Davey Tue, 17 Nov 2009 18:46:02 +0000 http://www.xconomy.com/?p=24501#comment-93118 All rather quiet right now, It could be a few months before we hear anything so heads up people! All rather quiet right now, It could be a few months before we hear anything so heads up people!

]]> By: Artista http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93092 Artista Tue, 17 Nov 2009 16:10:46 +0000 http://www.xconomy.com/?p=24501#comment-93092 Hey Shooter ~~"… or should we take it as an insult that “fitting in” means spelling everything incorrectly" I believe you hit the nail on the head. 'STEVE' and people like 'him' are nothing but parasites. Hey Shooter ~~”… or should we take it as an insult that “fitting in” means spelling everything incorrectly” I believe you hit the nail on the head. ‘STEVE’ and people like ‘him’ are nothing but parasites.

]]> By: Artista http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-93090 Artista Tue, 17 Nov 2009 16:07:20 +0000 http://www.xconomy.com/?p=24501#comment-93090 That spam was indeed a very sad attempt at suckering yet MORE people with their nonsense. Hope no one here would buy into it. Hey ZZ what is the status of your hair now? Its been a while since your treatment. I have read at the Baldingblog that Dr Rassman isnt impressed with the concept,or at least that was the impression i got from his words.Did you also read it? That spam was indeed a very sad attempt at suckering yet MORE people with their nonsense. Hope no one here would buy into it.
Hey ZZ what is the status of your hair now? Its been a while since your treatment. I have read at the Baldingblog that Dr Rassman isnt impressed with the concept,or at least that was the impression i got from his words.Did you also read it?

]]> By: Shooter http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-92520 Shooter Sun, 15 Nov 2009 06:08:34 +0000 http://www.xconomy.com/?p=24501#comment-92520 That was the most hilarious spam attempt I've ever seen. Three random facts that aren't pertinent to anything being discussed... and then a shameless plug for a horrible product. You get extra points for the horrible grammar and everything though... or should we take it as an insult that "fitting in" means spelling everything incorrectly, spewing meritless conjecture and using WAY too many ellipses? That was the most hilarious spam attempt I’ve ever seen. Three random facts that aren’t pertinent to anything being discussed… and then a shameless plug for a horrible product.

You get extra points for the horrible grammar and everything though… or should we take it as an insult that “fitting in” means spelling everything incorrectly, spewing meritless conjecture and using WAY too many ellipses?

]]> By: Metsie http://www.xconomy.com/boston/2009/05/13/follica-gets-new-ceo-gears-up-for-more-hair-and-business-growth/comment-page-22/#comment-92442 Metsie Sat, 14 Nov 2009 18:21:41 +0000 http://www.xconomy.com/?p=24501#comment-92442 Steve pack up and take the snake oil with you. If that crap worked so good you wouldn't have to sell it. Kevis is a joke and everybody knows it. Steve pack up and take the snake oil with you. If that crap worked so good you wouldn’t have to sell it. Kevis is a joke and everybody knows it.

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