Follica Gets New CEO, Gears Up for More (Hair and Business) Growth

5/13/09Follow @bbuderi

Follica, the Boston-area startup out to bring a scientific approach to helping hair-loss sufferers re-grow their locks, is preparing for some new growth of its own. The firm, run since its late 2006 inception by founding CEO Daphne Zohar of Boston’s PureTech Ventures, announced today the hiring of a new president and CEO, William Ju, a biopharmaceutical veteran with experience in an array of therapeutic arenas, including dermatology (he is a board certified dermatologist). The selection of Ju seems to position the firm to move out of the purely research-focused stage and closer to becoming a drug development company.

“There’s just a lot of excitement with regard to the science, and to the progress that’s been made,” Ju says of Follica’s work to date. “When I heard about the opportunity, I was really delighted with it, given my background as a dermatologist, given what I think is really breakthrough research.” And he says he looks forward to “bringing the company through to its next developmental stages.”

For her part, Zohar put it this way in a statement: “We are thrilled to welcome Bill Ju as the CEO of Follica. He brings the ideal blend of dermatology and drug development experience, creativity and leadership skills to Follica in this next exciting phase of development.”

What, exactly, Follica’s next step is—and when it will occur—is of intense interest to many of Xconomy’s readers, who struck up an often-spirited conversation on the site after we reported Follica’s $5.5 million Series A round in January 2008 and continued the discussion after the startup’s $11 million Series B funding last August. A lot of the talk in these comments has been centered on a 15 to 20 patient proof of concept study that Follica launched to put its follicle-generating approach to the test. Zohar confirmed the study’s existence last August, but the company has not provided other details on its progress—other than to stick to a general timeline laid out in January 2008 that no results would be available for at least a year. Depending on how you count, and when exactly the trial began, that year is either up or close to being up.

Which might or might not have something to do with Ju’s hiring. When I asked him about the trial, Ju, who started on May 1 and is still getting up to speed, was understandably vague. “The trial is … Next Page »

Bob is Xconomy's founder and editor in chief. You can e-mail him at bbuderi@xconomy.com, call him at 617.500.5926. Follow @bbuderi

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  • Artista

    @ J~~glad to see that humor is still prevalant here.

  • washington

    still well that still witty people exist here on follica, because I am not.

  • Zarko

    One thing I don’t understand.

    If they know all the ingredients and they are all approved, then why are they taking so long to study this out. I mean, give me their compound and I will find 50 guys and try various combinations and in a year I will have something to talk about for sure.

    They will release something in a matter of year or they have nothing because, if all ingredients are approved, that means that they don’t have to pass anything(FDA) and they will just put it suddenly. Or, they are screwed. That is what I think.

    Oh, one more thing, Follica is not a small company.

  • Metsie

    Haters,
    Why would Follica leave that NBC report on their web site? Just to fuck with a bunch of bald dudes? Relax.
    Artista how did the Cubs do last night ? lol
    J – LMAO

  • JS

    Shooter is right when he says proof of concept was supposed to have been done in 2008. Which makes all the other small bits of information that comes out every now and again more bizarre.

    This isn’t about hating on Follica, it’s more of a common sense WTF, what exactly have they been doing for over 2 years since they got funding, have they just been sat in an office hiring new people and deciding on the furnishings.

    The old saying, “actions speak louder than words” is perfect for this industry, I don’t think I’ve ever seen so many bluffers and bullshitters all in one profession.

    I don’t really understand why Cotsarellis hasn’t tested on a human without telling anyone either, I’m sure he could easily find someone he knows well who would gladly be a test subject. Sometimes following the rules doesn’t help anyone.

  • Ryan

    JS, I thought the same thing about him testing it on a human, there does seem to be a lack of people involved in science who are willing to take a chance, maybe that’s because of the culture of everybody suing for the slightest of problems. It’s sad that it holds things back though, I’m personally a great believer in taking risks to move things along faster, as long as everybody involved is aware of the dangers then it shouldn’t be a problem.

    I mean who amongst us wouldn’t have at least tried this idea on bald skin, look at the amount of people who have been doing home experiments without the knowledge a renowned scientist has. I find it hard to believe that he couldn’t have tested on an area of skin the size of a penny.

  • DBS

    http://stemcellbaldnesscures.com/company-news/follica/follica-takes-in-11-million-for-baldness-treatment-approach/

    In this link, Follica confirmed a proof of concept study was taking place. The article was dated April 15, 2009. If we go by what was said, a year or so would pass before we knew what took place in the study. Seems we’re coming towards that period right now.

    I’m not trying to shill for Follica, but let’s give it a bit more time. If we’ve heard nothing by mid-summer, or certainly the end of the year, then Follica probably flopped.

    Has anyone tried to contact some of the other members of Follica who are working on this like the Havard professor? Might be a better avenue than just Cotsarelis.

  • JS

    DBS, the information on that link was taken from one of the articles on xconomy, like the one you’re commenting on, and if you read the above article it says.

    “A lot of the talk in these comments has been centered on a 15 to 20 patient proof of concept study that Follica launched to put its follicle-generating approach to the test. Zohar confirmed the study’s existence last August, but the company has not provided other details on its progress—other than to stick to a general timeline laid out in January 2008 that no results would be available for at least a year. Depending on how you count, and when exactly the trial began, that year is either up or close to being up.”

    So the proof of concept was supposed to have happened in 2008 and the results should have been out sometime mid 2009.

    If anyone knows who they hired after that proof of concept happened, then maybe we could have an insight into whether the results were good or bad, because it’s for certain they won’t be telling anyone.

  • Ryan

    After reading your post JS I had a read of some of the other Follica articles on here, and here’s a couple of other quotes that show they definitely have had some type of study or trial.

    In one article dated December 2008 Daphne Zohar said.

    “Zohar yesterday confirmed that a pilot study is underway but wouldn’t confirm where or give any other details on its timing other than to tacitly stick to the timeline she laid out in January, when she said that final data from the study would not be available for at least a year. “Everything is progressing on track,” she now says. “We are moving as quickly as possible within the constraints of clinically driven medicine.”

    Zohar also demurred when I asked about the reports in the reader comments on our story from January that the study only involves testing small patches of dermabrasion without administering any drugs to the wounds. In fact, she wouldn’t even confirm that the researchers were using dermabrasion to create the wounds in the first place. “At this point we are looking at the human response to disruption and the timing of the human ‘embryonic window’ post disruption,” she said. “Disruption,” she added, “is not necessarily the same as dermabrasion.”

    So the proof of concept was supposed to have happened in late 2008 and the results should have been out sometime late 2009.

    Another part of the above article has a quote from William Ju who had just started working there and he also said in May 2009.

    “The trial is ongoing, the trial is going well,” he says. “Once I get a chance to evaluate that, I’ll have a better sense.” He did add this: “I’ve certainly been pleased with the way things are going…A lot of it is really getting into the details and confirming from a quality perspective what you see with regard to the data points.”

    So the trial has happened. You would think they would have some results by now.

  • Jordan

    Hmmm maybe they just want to bang a product on the shelfs just like that. Histogen has told us how they are doing, and it puts pressure on othe companies. Follica haven’t said anything, few hints. Maybe they are going to surprise everyone?

  • Maverick

    Zohar on my native language means cockroach so it is no wonder that she is bailing out. ;)

  • tim
  • Artista

    Thanks Tim great article ,,i noticed that it was first published in January of this year. I had not seen this one so thanks again

  • iwantsomehair

    Guys I urge you all to please settle down on kocking Follica to the ground. The proof of concept results probably should have been released at the end of 2009. However, please keep in mind we are just 4 months into 2010. I would hope to expect something by the end of this year but if we don;t then I still don;t think it’s all bad. I understand patience is a tough game right now. Each day we all get a little less attractive but everyday they get a little closer to a viable treatment.

    In my opinion follica has not bothered me at all. I’m sure thety are failry close to coming out with a statement. In my book they are right on track with what their nbc interview would indicate.

  • JS

    iwantsomehair, I’d love to think they were on track with their NBC interview becaue that would mean we’d have their treatment out in either 2011 or 2012, but going off what Dr Cotsarelis said in this link that ZZ provided earlier that doesn’t look anywhere near likely.

    http://citypaper.net/articles/2009/01/22/george-cotsaleris-hair-follicle-research

    What he says here is a bit dissapointing.

    “Without pinning himself to a timeline, the good doctor’s estimate for Follica’s treatment looks very possible for launch within the next five years. “It’s impossible to know for sure, but within the next several years — two to three — there’ll be a trial where we’ll use a procedure with the compound to see if it works in humans,” says Cotsarelis. “There will be the usual regulatory stuff after that, so perhaps in four to five years we’ll have something we can offer people.”

    That was a year ago, it now looks like the earliest the Follica treatment will be available will be about 2015, and that’s probably if everything goes very well in testing.

    It looks like we’re back to the old joke of 5 years away.

  • Billy

    Something is right with follica, In the article above Dr Cotsarelis said in the next two to three years there will be a trial. But when Follica got a new CEO, he mention there is proof of a trail? It doesnt add up!

  • iwantsomehair

    4-5 years from 2009. So I see 2013-2014. There could also be an element to under promise and over deliver from him. I mean guys do you all understand the treatment is most likely here! very exciting shit!

  • deluxe

    Lets look at it from a different perspective…the perspective of people who are highly invested in Follica…

    Let us assume for a second that they did in fact have trials, and these trials happened to show tremendous hair growth…more than what was expected. All of a sudden, you have something so great on your hands, especially since it is probably very easy to replicate the process, that now all you can do is keep it secret.

    On the flip side, lets say that their trials did not go as well as they had hoped. Now, I can see the Follica team making an announcement of how trials were good but not great, and they need to work it out some more. They would come out with mediocre results as not to remove themselves from the public eye, especially if their trials and process was going to take much longer than expected.

    IF they did in fact have significant results, say even close to a cure or a perfected treatment…they would probably want to take the approach of staying silent and then releasing a product sooner than expected, surprising not only the public but their competition as well. If they know that they can have a product out sooner than later, why put yourself in the limelight, when there is no reason to.

    I believe that follica will have something perfected. Perhaps even to the point of just selling do-it-yourself kits.

    This may be far fetched, but if the hair grows significantly and in the way that nature intended, the biggest worry is in the hairline. For this, I could even see them introducing a plastic natural hairline cut out that could be custom fit to the forehead and sticks to it. After that, you would apply the dermabrasion gel all over the scalp and apply the wnt product. This could possibly be a tactic that Follica may be getting ready to introduce.

    Remember guys, they did graft human skin on to the mice and still grew hair. Consider that your “proof of concept”.

  • deluxe

    One more thing to consider…

    Since Follica’s process is so simple, they may not want to run the risk of people trying it on themselves, especially since their patents are available to view. The FDA could even have a hand in this, pressing them to hold off on any good news of the treatment until they actually release their product. This would ofcourse definitely keep desperate hairloss patients from trying to do this process on their own since they could now just go and buy the product. What would follica get out of listening to the FDA even thought they aren’t required to? Quicker approval from the FDA.

    Put yourself in Follica’s shoes.

  • Jacob

    Their trial or study whatever you want to call it was to test the wounding process, in that interview with Cotsarelis above he says

    “It’s impossible to know for sure, but within the next several years there’ll be a trial where we’ll use a procedure with the compound to see if it works in humans,”

    That to me sounds like they were still developing the procedure they were going to use with the compound, we saw that device they patented last year for a dermabrading and drug delivery tool, if we’re really lucky then maybe that’s an indication that they have moved along a bit and that is the procedure that they’ve been developing. But the longer they wait to test the whole procedure on humans then the longer it will take to come to market.

    I think it’s good that we’ve actually started talking about Follica on here again, like someone else said they were the reason we all found this place. Unfortunately it does look to be years away still, unless they know of a rapid way to move through clinical trials.

  • Shooter

    I appreciate the optimistic “what-if” scenarios, I just find them to be extremely unlikely.

    As far as I remember, they never grew “hair” on the backs of the mice with human skin grafts. They noticed new hair follicles forming… but I’m not sure they ever saw hair shafts coming from those follicles. This is pretty important, imo.

  • Maverick

    “Unfortunately it does look to be years away still, unless they know of a rapid way to move through clinical trials.”

    Maybe they will market it somewhere where FDA does not mean nothing. For me it will not be a problem traveling wherever it needs to go. I don´t know why are you so scared about these trials. If US laws continues to make obstacles they will simply move their research to somewhere where there aren´t these law obstacles. With all due respect but FDA and restrictive laws can suck my ass outside USA.

  • Ryan

    I guess we’ll just have to wait and see with Follica, I’m sure most of you are bored of talking about Follica now so I’ll try and post less about them, just before I do I’d like to share something that made me laugh when I found it and show another reason why there’s been a lot of confusion surrounding Follica, this is a small article from 2008 and the comments from David Steinberg about human testing and the time it will take for it to come to market show why many people feel like they’ve been mislead.

    “We’re testing various different dermatological procedures and drug interventions to maximize the effect,” said Steinberg, whose company has licensed the technology developed by Cotsarelis. “We’ll be testing in humans within a year.”

    If all goes well, Steinberg said, bald men will be able to undergo the procedure at doctor’s offices within a couple of years.

    Because the procedure would involve derm abrasion or other less-invasive methods of removing the top layer of skin and then applying growth-inducing drugs, Steinberg said: “This is definitely a don’t-try-this-at-home kind of thing.”

    Follica, founded in September 2005, has just a handful of employees and is one of eight businesses backed by Boston’s Puretech Ventures, but the study’s results are ‘huge for us,” Steinberg said.

    “The hair growth market is between $2 billion and $4 billion, with nothing out there that actually works all that well,” said Steinberg. That includes hair transplants, drug treatments, laser procedures and “all the late-night infomercial stuff,” Steinberg said. He added that the market could be much bigger if you take into account the fact that many bald men have just given up hope.

    Steinberg said the research holds even wider promise for Follica: “This could have implications for skin and wound rejuvenation, too, and maybe acne.”

    http://www.manticeye.com/article.php?id=1142_0_2_0_C

    Well if David was right we should have it coming out in the next year or so.

  • DBS

    I’m glad this discussion has come back to Follica and I think it holds far more promise than most think. Unfortunately, I know it’s likely to be 5-7 years before this really comes to fruition.

    In retrospect, I do wonder if Follica hit some sort of wall. Given the excitement they showed three years ago, it seems unusual no trials or results from a trial would be available by now.

    Until they give us some sort of news, it’s probably best to just move on from the topic. Can we get Xconomy to press for an on the record story?

  • rev

    I’m done defending Cots and Crew. I want to see some tangible proof before we grace them with yet another sloppy proverbial handjob.

  • Ryan

    DBS, Robert Bunderi has tried before to get information from them, the last thing he was able to get was in this article on xconomy from Jauary of this year.

    http://www.xconomy.com/boston/2010/01/22/a-very-brief-follica-update-for-our-loyal-readers/comment-page-2/#comment-110231

    Like he said, the comments are very vague and are similar to what other companies say when they don’t have much new to impart or want to raise people’s expectations.

  • Informant

    AUTHORS (FIRST NAME INITIAL LAST NAME): G. Naughton1, M. Zimber1, C. Ziering1, M. Hubka1, R. Kellar1, K. Hubka1, D. Perez-Mesa2, J. Mansbridge1
    INSTITUTIONS (ALL): 1. Histogen, San Diego, CA, United States.
    2. Medical Hair Restoration, Maitland, FL, United States.

    ABSTRACT BODY: Research has shown the importance of Wnt 7a and wound healing growth factors on the stimulation of bulge cells and inter-follicular stem cells to induce hair growth. We have developed a bioengineered human cell-derived formulation, termed Hair Stimulating Complex (HSC), consisting of growth factors and morphogens recognized to be critical to the induction and maintenance of hair follicle growth. Following preclinical safety and efficacy studies suggesting the increased induction of anagen in the C57Bl model by HSC, a clinical pilot study was undertaken. The double-blind, placebo-controlled, randomized single site trial was primarily designed to evaluate safety of the HSC product, with efficacy as a secondary goal. Data analysis indicated that HSC is safe and showed effectiveness in stimulating hair growth in subjects with MPHL. All subjects tolerated the procedures well, no adverse reactions were reported. Histopathological evaluation of the treatment site biopsies taken at 22 & 52 wk post-treatment revealed no abnormal morphology, hamartomas or other pathological responses. Trichoscan image analysis of placebo sites at 12, 22 & 52 wk showed no significant improvements in any of the measured hair growth indicators over the initial 12wk evaluation period whereas the HSC treated sites demonstrated an increase in all hair growth indicators except vellus hair density. The improvements from HSC treatment were significantly greater than that observed in placebo treated sites: hair shaft thickness (6.3% + 2.5% vs. -0.63% + 2.1%; p = 0.046), thickness density (12.8% + 4.5% vs. -0.2% + 2.9%; p = 0.028), and terminal hair density (20.6 + 4.9% vs. 4.4 + 4.9%; p = 0.029). Similar trends were seen at 22 & 52 wk, with total number of hairs increasing on the HSC-treated site only over one year. These results clearly demonstrate that a single intradermal administration of HSC improved hair growth in subjects with androgenetic alopecia and is a clinical substantiation of previous preclinical research with Wnts and wound healing.

  • A
  • ZZ

    According to http://www.thebaldtruth.com/

    Dr. Naughton states that Histogen has “received the substantial funding needed to underwrite the additional studies that are soon to take place in Singapore”

    This appears to be a step forward from the statement last week that they had a commitment for funding. As you may remember, the last commitment they were closing in on in November 2009 fell thru.
    IMO, there is or was an upside to hearing no positive updates from Histogen’s competitors until Histogen raises needed funding.

  • Artista

    I completely AGREE with ZZ. Keep all of your hopes alive guys.

  • Jordan

    Were getting there, i cant wait till i never have to worry about my hair, only bad hair days ha ha

  • iwantsomehair

    Invest in a good hair piece or weave to last you the next 4-5 years. Im positive some amazing treatment will come out within the next 4-5 years.

    I want a weave. My dad has one and it looks decent.

    Anyone know anyone with a weave?

  • DBS

    Maybe I’m missing something, but it seems the info provided by Informant seems to substantiate the Follica process even though it comes from Histogen. I’m not much for the invasive processes like cloning, but the Histogen news seems to alleviate any concern there might be adverse affects from a Follica style treatment. If so, maybe good news is closer than we tink. I doubt it, but the path is getting clearer as to how to grow real hair on a bald head, not just peach fuzz.

  • JS

    DBS, I don’t think anyone is doubting the science behind Follica, the problem is the lack of trials on humans. They should have tested it by now.

  • J

    iwantsomehair I dont think it is going to take 4-5 yrs I actually think we will see something way befor that.

  • Dai

    I am not sure if Follica has actually come out and said that they have not conducted human trials or if we are just assuming that based on their silence. Could it be that they have actually begun human trials but outside the US ? Quite a bit of medical testing is outsourced to Asia these days, especially at the initial stages. Cheaper, faster, less paperwork, larger data sample size etc. Just a thought…

  • Jacob

    Dai, Dr Cotsarelis said on his University of Penn website that they hadn’t started trials yet and had no plans to. I had to go back through the comments on here to find the original post from shooter and here it is.

    http://www.uphs.upenn.edu/news/News_Releases/may07/hair-follicle-regeneration.html

    Wile I was looking through the old comments I came across the comments about that patent Follica got for “METHODS, KITS, AND COMPOSITIONS FOR GENERATING NEW HAIR FOLLICLES AND GROWING HAIR” I don’t remember it being that in depth the first time I saw it, if you go to description on this link you’ll see what I mean. If you also go to legal status, the date on their says they did something on the 20 January 2010, does anyone know what? was it just an extension, I’m not entirely sure.

    http://v3.espacenet.com/publicationDetails/description?CC=EP&NR=2077819A2&KC=A2&FT=D&date=20090715&DB=EPODOC&locale=en_EP

  • Artista

    @iwantsomehair your fathers weave looks ok to you? I had never considered anything like that. Is it something to give a thought to? what does all think here.?

  • iwantsomehair

    J what maks you think sooner than 4-5 years?

  • Informant

    Some new studies from Cotsarelis..

    AUTHORS (FIRST NAME INITIAL LAST NAME): C. Yang1, 2, D. Gay2, G. Cotsarelis2
    INSTITUTIONS (ALL): 1. Dermatology, National Cheng Kung University, Tainan, Taiwan.
    2. Dermatology, University of Pennsylvania, Philadelphia, PA, United States.

    ABSTRACT BODY: Reconstitution of hair follicles has been established by using dissociated cells from murine skin, but a reconstitution assay for human hair follicles is still lacking. The aim of our study was to develop a reconstitution assay for human hair follicles. We used human fetal scalp, 16 to 18 weeks gestational age, to provide the starting cell populations for hair follicle reconstitution. Epidermis and dermis were separated and single cells isolated from scalp tissue. The cells were recombined and injected into the back skin of immunodeficient mice. 3 weeks after injection, hair germs were evident. By 5 weeks, fully formed hair follicles and pigmented hair shafts were visible. The regenerated hair follicles contained all follicular epithelial lineages. The human origin of the regenerated follicles was confirmed using in situ hybridization for Alu DNA repeats specific for human. To test whether Matrigel facilitates survival and growth of the cell grafts, we added Matrigel to the suspension of cells before injection. We found that Matrigel rescued trichogenicity and resulted in a higher number of regenerated hair follicles.

    TITLE: The role of Prostaglandin D2 and its receptor DP-2 in promotion of Androgenetic Alopecia

    AUTHORS (FIRST NAME INITIAL LAST NAME): L. A. Garza1, B. Alagesan2, J. A. Lawson3, S. M. Norberg2, E. Loy1, T. Zhao2, D. C. Stanton4, L. Carrasco4, S. M. Fischer5, G. A. FitzGerald3, G. Cotsarelis2
    INSTITUTIONS (ALL): 1. Dermatology, Johns Hopkins, Baltimore, MD, United States.
    2. Dermatology, University of Pennsylvania, Philadelphia, PA, United States.
    3. Pharmacology, University of Pennsylvania, Philadelphia, PA, United States.
    4. OMFS, University of Pennsylvania, Philadelphia, PA, United States.
    5. Science Park, MD Anderson, Smithville, TX, United States.

    ABSTRACT BODY: To better understand the pathogenesis of androgenetic alopecia (AGA), we have performed global gene expression analysis on paired haired and bald scalp samples from 5 individuals undergoing hair transplantation for male pattern baldness. The Lipocalin type of Prostaglandin D2 Synthase (L-PGDS) was upregulated (p<0.01) in bald compared to haired scalp. RT-PCR (n=4, p<0.04) and western blotting (n=4, p<0.01) confirmed increases in L-PGDS mRNA and protein expression respectively. By ELISA (n=3, p<0.01) and mass spectrometry (n=17, p<0.01), we found increased PGD2, the enzymatic product of L-PGDS, in bald versus haired scalp. PGE2, which often antagonizes PGD2 actions, was decreased in bald scalp (n=17, p<0.01). As a mouse model of increased levels of PGD2, the K14-COX2 mouse develops alopecia and sebaceous hyperplasia reminiscent of that seen in AGA. In an in vitro explant model (n=16, p<0.01), PGD2 and 15d-PGJ2 inhibit human hair growth. PGD2 and 15d-PGJ2 also inhibit mouse hair growth when applied topically (n=3, p<0.05) to wild type mice. To investigate the mechanism, we sought to determine which receptors were required for PGD2 inhibition of hair growth. PGD2 was applied to mice null for the DP-1 and DP-2 canonical PGD2 receptors, as well as L-PGDS null mice as a control. PGD2 inhibited hair growth in DP-1 and L-PGDS but not DP-2 null mice (n=3, p<0.05). Together these data support a role for PGD2 and the DP-2 receptor in the development of AGA thus provide new targets for possible hair loss treatments.

  • j

    iwantsomehair, I just think w all the people working on this and w some of the previous time lines that we should see something soon. even without follica things look pretty good.. Im pretty upset though that follica has even come out and done a interview like the one for msnbc if he wasnt 100% sure they would have something to market when they said!!! I just wish Cotserelis was bald himself!!! that would have helped!!!

  • DBS

    Anyone care to decipher what the Cotsarelis studies say?

    If he’s still working on mice, then I guess any hope for forthcoming good news in not in the cards. Seems like growing hair isn’t really a problem anymore. Both Follica and Histogen have shown that.

  • Artista

    DBS dont let pessimism gEt the best of you my friend.

  • Jordan

    I don’t understand that abstract :S

  • ZZ

    Jordan, They are saying that they compared balding to no-balding scalps and found that a hormonelike substance (PGD2) was prevalent in the balding scalp and that another hormonelike substance (PGE2)which keeps PGD2 in check was deficient in balding scalps. Therefore, they are suggesting that finding a way to either block the action of PGD2 or increasing PGE2 might help treat AGA. This is just another illustration of how complex the solution is. It seems that there is just no end to the proteins, sub-proteins, receptors, hormones, signaling pathways, stem cell types, cycling, etc that are involved in hair growth. That being said, I believe we are very close to taking a very positive step forward. Some encouraging numbers from Histogen: “the numbers shown in the slides do show a 47.21% increase (179 to 263) which represents the increase in total hair count. In reviewing the actual numbers in the clinical data, the 73.61% increase is actually the increase in the terminal hairs in that subject.” This is only 1 subject but it is also only a safety dosage. Keep your fingers crossed.

  • Jordan

    Wow, thanks ZZ. They know so much more about hair loss, genes etc. I really hope they hit the nail on the head.

    Fingers crossed

  • Artista

    Thanks ZZ once again. Great input. As i have been saying guys, remain calm ,dont allow pessimism to get the better of you. When a company goes silent that doesn’t mean ‘doom and gloom’. Follica and the like do not owe ANY of us anything. If and when they put something viable on the market do you think they worry that the majority of the public will turn their collective backs because they were kept in the dark during the lab testing years? The revenue created will be stupendous. This is an exciting time if you allow yourself to look at it that way.

  • JS

    Artista, I don’t think it’s a case of people believing the likes of Follica owe us anything, it’s simply just a desire to know that they’ve tested their treatment on humans and it works. That’s all anybody wants to hear and I personally don’t think it’s too much to ask for and I also don’t think it would harm Follica in any way, shape or form.

    I don’t know whether the new Cotsarelis study is a positive or a negative thing in connection with the Follica treatment, Maybe they’ve finished developing the Follica treatment and he’s moved on to other areas of research, or maybe this is connected to Follica and could be an indication that they hit a brick wall somewhere along the way, explainig the delay in trials.

  • Shooter

    Those studies are interesting.

    The first study is very Aderans-esque… which is odd given that Cotsarelis SHOULD be pursuing Wnt/Wounding hair regrowth.

    It sounds like good news though, because I remember reading an article where Ken Washenik from Aderans said they couldn’t get human hair follicles to grow on mice (even though they were supposed to). It seems Cotsarelis found out how.

    I really don’t know what to make of any of this. I really have no clue if we’re 3 years away or 30. All of these random studies don’t seem to be going anywhere… which is frustrating.

  • Ryan

    Shooter you hit the nail on the head about theses studies, they all sound promising but ultimately don’t seem to lead anywhere.