Comments on: Sirtris Returns to Its “Roots” in Crop Deal with Bayer http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/ Business + Technology in the Exponential Economy Sat, 21 Nov 2009 22:30:41 -0600 http://wordpress.org/?v=2.8.6 hourly 1 By: Robert Kavanaugh http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-83883 Robert Kavanaugh Mon, 28 Sep 2009 23:55:26 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-83883 My research indicates that soy isoflavones, especially the diadzein metabolite S-equol is a potent Sirtuin 1 activator, potentially 1000 times more effective than resveratrol. Trouble is, only about 50-80% of the population are "equol" producers. So, you have to be healthy to be healthier. Isn't that kind of like money? My research indicates that soy isoflavones, especially the diadzein metabolite S-equol is a potent Sirtuin 1 activator, potentially 1000 times more effective than resveratrol. Trouble is, only about 50-80% of the population are “equol” producers. So, you have to be healthy to be healthier. Isn’t that kind of like money?

]]> By: ruth rosen http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-44967 ruth rosen Mon, 26 Jan 2009 06:47:06 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-44967 I am interested to know if resveratrol would be helpful in controlling conditions such as osteo arthritis. Is a natural form available for safe use or not. the letters were confusing. if we all live to more than 100 who will support us? will retirement age be moved up to 90? how will the youth find employment and what if men sire children into their 90's? I think there a lot of social implication to these improvements I am interested to know if resveratrol would be helpful in controlling conditions such as osteo arthritis. Is a natural form available for safe use or not. the letters were confusing. if we all live to more than 100 who will support us? will retirement age be moved up to 90? how will the youth find employment and what if men sire children into their 90’s? I think there a lot of social implication to these improvements

]]> By: Mark Yennik http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-10409 Mark Yennik Sat, 29 Mar 2008 01:47:04 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-10409 Does the French paradox apply to smoking? I'd appreciate a pill that lets me smoke, drink, and stuff my face with croissants while losing weight and living to 150. Every one of those French bastards skarfs down cigarettes while guzzling red wine, oggling women, avoiding work and trashing America. Talk about the life! Does the French paradox apply to smoking? I’d appreciate a pill that lets me smoke, drink, and stuff my face with croissants while losing weight and living to 150. Every one of those French bastards skarfs down cigarettes while guzzling red wine, oggling women, avoiding work and trashing America. Talk about the life!

]]> By: James Betz http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-8982 James Betz Fri, 14 Mar 2008 14:40:40 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-8982 The above was a joke post. Please regard it as such. I have no idea if Biotivia is a good product or not. The only thing I can tell you is that the guy finds every Sitris or Resveratrol forum/blog that he possibly can find and attempts to market his product while bashing others. Its sad really. The above was a joke post. Please regard it as such.

I have no idea if Biotivia is a good product or not. The only thing I can tell you is that the guy finds every Sitris or Resveratrol forum/blog that he possibly can find and attempts to market his product while bashing others.

Its sad really.

]]> By: James Betz http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-8981 James Betz Fri, 14 Mar 2008 14:37:19 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-8981 Transmax is a cheaply produced resveratrol supplement that is purchased from shady sources in China that we never bothered to test for purity or heavy metals. Fortunately, my company makes its money riding on media hype and consumer ignorance which lets me mark up my cheap product for a hefty profit. I can then in turn pay people to scour the internet to pump my product and bash competitors and real parmacutical companies such as Sitris where ever i find a blog or forum. Transmax is a cheaply produced resveratrol supplement that is purchased from shady sources in China that we never bothered to test for purity or heavy metals.

Fortunately, my company makes its money riding on media hype and consumer ignorance which lets me mark up my cheap product for a hefty profit.

I can then in turn pay people to scour the internet to pump my product and bash competitors and real parmacutical companies such as Sitris where ever i find a blog or forum.

]]> By: Anthony Loera http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-8979 Anthony Loera Fri, 14 Mar 2008 14:30:35 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-8979 I have to say, I really like this partnership. Who knows, it may help provide a competitor to Monsanto down the line. (Which in my opinion is badly needed.) I have to say,

I really like this partnership. Who knows, it may help provide a competitor to Monsanto down the line. (Which in my opinion is badly needed.)

]]> By: Wade Roush http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-8944 Wade Roush Thu, 13 Mar 2008 23:43:33 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-8944 Seeing all the outlandish comments from self-styled "Doctors" that crop up (pun not originally intended) every time we publish a story about Sirtris, I can understand why the company is so hyper-cautious about the potential nutraceutical uses of sirtuin-inducing compounds. What a minefield of conflicting claims and snake-oil salesmen. Seeing all the outlandish comments from self-styled “Doctors” that crop up (pun not originally intended) every time we publish a story about Sirtris, I can understand why the company is so hyper-cautious about the potential nutraceutical uses of sirtuin-inducing compounds. What a minefield of conflicting claims and snake-oil salesmen.

]]> By: Dr. George http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-8937 Dr. George Thu, 13 Mar 2008 21:12:12 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-8937 "Biotivia Transmax" is just a trade name for one particular Resveratrol supplement. Resveratrol is rapidly becoming a commodity supplement, and there are a number of quality providers. "Dr. Harding" is a Biotivia sockpuppet who spams every website he can find, attempting to implant this false message that "biotivia transmax" is somehow the accepted nomenclature for "natural resveratrol". “Biotivia Transmax” is just a trade name for one particular Resveratrol supplement. Resveratrol is rapidly becoming a commodity supplement, and there are a number of quality providers. “Dr. Harding” is a Biotivia sockpuppet who spams every website he can find, attempting to implant this false message that “biotivia transmax” is somehow the accepted nomenclature for “natural resveratrol”.

]]> By: Alexander Mark http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-8936 Alexander Mark Thu, 13 Mar 2008 21:12:02 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-8936 Dr. Harding. Aside from any benefit that might be derived via a new formulation (and it could be substantial)there is the simple idea that you cannot make money off natural substances because you cannot market them. It seems to be a questionable stance to not look into potential benefits of synthetic varieties. Until we know we are guessing. Dr. Howlings. I ingest considrable amounts of the root of a plant that contains notable amounts of resvrtrol. Within 30 minutes the feeling being more robust becomes noticable. the loss of excess body fat has not hurt either. I realize that I might suffer unknown negative side effects but after reviewing the literature I decided that the risk to reward ratio was one I will live with. Since people in my family tend to die on the left side of the bell curve (the joke is I am saving for my wife's retirement) I feel that it is hopefully a good effort. I am inclined to simply point out that there might be natural forms of the substance that are bioavailable. I am not endorsing the product you mentioned. i certainly understand that my experiance should be regarded as anecdotal. Dr. Harding. Aside from any benefit that might be derived via a new formulation (and it could be substantial)there is the simple idea that you cannot make money off natural substances because you cannot market them. It seems to be a questionable stance to not look into potential benefits of synthetic varieties. Until we know we are guessing.

Dr. Howlings. I ingest considrable amounts of the root of a plant that contains notable amounts of resvrtrol. Within 30 minutes the feeling being more robust becomes noticable. the loss of excess body fat has not hurt either. I realize that I might suffer unknown negative side effects but after reviewing the literature I decided that the risk to reward ratio was one I will live with. Since people in my family tend to die on the left side of the bell curve (the joke is I am saving for my wife’s retirement) I feel that it is hopefully a good effort. I am inclined to simply point out that there might be natural forms of the substance that are bioavailable. I am not endorsing the product you mentioned. i certainly understand that my experiance should be regarded as anecdotal.

]]> By: Dr, Bernard Howlings http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-8901 Dr, Bernard Howlings Thu, 13 Mar 2008 02:59:17 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-8901 I see Sirtris as a company on the leading edge of drug development in the sirtuin space. The problem with natural supplements, such biotivia transmax is that they are not bioavailable and offer no proven benefits. Natural supplements such as biotivia transmax make many false claims and are a waste of money. I see Sirtris as a company on the leading edge of drug development in the sirtuin space. The problem with natural supplements, such biotivia transmax is that they are not bioavailable and offer no proven benefits. Natural supplements such as biotivia transmax make many false claims and are a waste of money.

]]> By: Dr. James Harding http://www.xconomy.com/boston/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/comment-page-1/#comment-8897 Dr. James Harding Thu, 13 Mar 2008 01:37:52 +0000 http://www.xconomy.com/2008/03/12/sirtris-returns-to-its-roots-in-crop-deal-with-bayer/#comment-8897 As I see it the dilemma for Sirtris is that the products they are developing already exist in effective natural, inexpensive form. Given, his synthetic analogs may be more potent or targeted against specific conditions such as diabetes however biotivia transmax, the natural form of concentrated resveratrol, is available now and has been shown in peer reviewed studies to be safe and effective. Synthetic analogs historically have been shown to be somewhat unpredictable in effect and safety. Why not simply stick with the natural form? As I see it the dilemma for Sirtris is that the products they are developing already exist in effective natural, inexpensive form. Given, his synthetic analogs may be more potent or targeted against specific conditions such as diabetes however biotivia transmax, the natural form of concentrated resveratrol, is available now and has been shown in peer reviewed studies to be safe and effective. Synthetic analogs historically have been shown to be somewhat unpredictable in effect and safety. Why not simply stick with the natural form?

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