Lloyd M. Smith is the W. L. Hubbell Professor of Chemistry and Director of the Genome Center at the University of Wisconsin-Madison, where he has been since 1988. He received an A.B. degree in Biochemistry from the University of California at Berkeley (1977) and a Ph.D. in Biophysics from Stanford University (1981). In 1982 he moved to the California Institute of Technology, where he developed the first fluorescence-based automated DNA sequencing instrument.
He has been named one of Science Digest's Top 100 Innovators and has received the Presidential Young Investigator Award, Eli Lilly Analytical Chemistry Award, Association of Biomolecular Resource Facilities Award for the development of automated DNA sequencing, American Chemical Society Award in Chemical Instrumentation, the Pittsburgh Analytical Chemistry Award, and is a Fellow of the AAAS. He has served on the NIH National Human Genome Research Institute Advisory Council, the NIH Human Genome study section, and the NIH Instrumentation and Systems Development study section (chair from 2008-2010).
He is an author of over 230 scientific papers and inventor on 29 issued U.S. patents. He is a founder of the biotechnology company Third Wave Technologies, which was acquired in June 2008 by Hologic, Inc. for $580M. He served for many years on the Board of Directors of two public companies (Visible Genetics and Third Wave Technologies). His primary area of research is in the development of new technologies for the analysis and manipulation of biomolecules.